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Macrolide Allergic Reactions

机译：大环内酯类过敏反应

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Macrolides are antimicrobial agents that can be used to treat a variety of infections. Allergic reactions to macrolides occur infrequently but can include minor to severe cutaneous reactions as well as systemic life-threatening reactions such as anaphylaxis. Most reports of allergic reactions occurred in patients without prior exposure to a macrolide. Cross-reactivity among macrolides may occur due to the similarities in their chemical structures; however, some published literature indicates that some patients can tolerate a different macrolide. Most published reports detailed an allergic reaction to erythromycin. Desensitization protocols to clarithromycin and azithromycin have been described in the literature. The purpose of this article is to summarize macrolide-associated allergic reactions reported in published literature. An extensive literature search was conducted to identify publications linking macrolides to hypersensitivity reactions.
机译：大环内酯类是抗菌剂，可用于治疗多种感染。对大环内酯类药物的过敏反应很少发生，但可能包括轻度至重度的皮肤反应以及危及生命的全身性反应，例如过敏反应。大多数过敏反应的报告都发生在未事先接触大环内酯的患者中。大环内酯类之间的交叉反应可能是由于其化学结构的相似性造成的。但是，一些公开的文献表明，某些患者可以耐受不同的大环内酯类药物。大多数发表的报告都详述了对红霉素的过敏反应。在文献中已经描述了对克拉霉素和阿奇霉素的脱敏方案。本文的目的是总结已发表文献中报道的大环内酯类相关的过敏反应。进行了广泛的文献检索，以确定将大环内酯类药物与超敏反应联系起来的出版物。

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