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首页> 外文期刊>Pharmacy >Implementing Clinical Pharmacogenomics in the Classroom: Student Pharmacist Impressions of an Educational Intervention Including Personal Genotyping
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Implementing Clinical Pharmacogenomics in the Classroom: Student Pharmacist Impressions of an Educational Intervention Including Personal Genotyping

机译：在课堂上实施临床药物基因组学：包括个人基因型在内的教育干预对学生药剂师的印象

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Pharmacogenomics provides a personalized approach to pharmacotherapy by using genetic information to guide drug dosing and selection. However, partly due to lack of education, pharmacogenomic testing has not been fully implemented in clinical practice. With pharmacotherapy training and patient accessibility, pharmacists are ideally suited to apply pharmacogenomics to patient care. Student pharmacists ( n = 222) participated in an educational intervention that included voluntary personal genotyping using 23andMe. Of these, 31% of students completed both pre- and post-educational interventions to evaluate their attitudes and confidence towards the use of pharmacogenomics data in clinical decision making, and 55% of this paired subset obtained personal genotyping. McNemar’s test and the Wilcoxon signed-rank test were used to analyze responses. Following the educational intervention, students regardless of genotyping were more likely to recommend personal genotyping (36% post-educational intervention versus 19% pre-educational intervention, p = 0.0032), more confident in using pharmacogenomics in the management of drug therapy (51% post-educational intervention versus 29% pre-educational intervention, p = 0.0045), and more likely to believe that personalized genomics would have an important role in their future pharmacy career (90% post-educational intervention versus 51% pre-educational intervention, p = 0.0072) compared to before receiving the educational intervention. This educational intervention positively influenced students’ attitudes and confidence regarding pharmacogenomics in the clinical setting. Future studies will examine the use of next-generation sequencing assays that selectively examine pharmacogenes in the education of student pharmacists.
机译：药物基因组学通过使用遗传信息指导药物剂量和选择，提供了个性化的药物治疗方法。但是，部分由于缺乏教育，药物基因组学测试尚未在临床实践中完全实施。通过药物治疗培训和患者可及性，药剂师非常适合将药物基因组学应用于患者护理。学生药剂师（n = 222）参加了一项教育干预活动，其中包括使用23andMe进行自愿性个人基因分型。其中，有31％的学生完成了教育前后的干预，以评估他们对在临床决策中使用药物基因组学数据的态度和信心，而这对配对子集中的55％获得了个人基因分型。 McNemar的测试和Wilcoxon秩和检验用于分析响应。在进行教育干预之后，无论基因型如何，学生都更倾向于推荐个人基因型（教育后干预的比例为36％，教育前干预的比例为19％，p = 0.0032），他们对使用药物基因组学进行药物治疗的管理更有信心（51％）教育后干预与29％教育前干预相比，p = 0.0045），并且更有可能相信个性化基因组学将在他们未来的药学事业中发挥重要作用（教育后干预的比例为90％，教育前干预的比例为51％， p = 0.0072）与接受教育干预之前相比。这种教育干预积极地影响了学生对临床环境中药物基因组学的态度和信心。未来的研究将研究下一代测序测定法的使用，该测定法在学生药剂师的教育中选择性地检查药物基因。

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