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首页> 外文期刊>Pharmacognosy Research >Antianaphylactic and mast cell stabilization activity of Strychnos potatorum Linn. seed
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Antianaphylactic and mast cell stabilization activity of Strychnos potatorum Linn. seed

机译：Strychnos potatorum Linn的抗过敏和肥大细胞稳定活性。种子

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Aim:The antianaphylactic activity of Strychnos potatorum Linn seed extract was evaluated by using compound 48/80 induced anaphylaxis and mast cell stabilization was studied by using peritoneal mast cells of rats. The possible antianaphylactic and mast cell stabilization mechanism was evaluated by using compound 48/80 induced mast cell activation and level of nitric oxide in rat peritoneal mast cells.Materials and Methods:Anaphylactic shock in mice was induced by the intraperitoneal administration of 8 mg/kg compound 48/80, prior to induction of anaphylaxis the animals were treated with S. potatorum Linn. seed extract administered orally 1 h before administration of compound 48/80, the rate mortality was observed in each group of animals. Mast cell stabilization was seen by preincubation of mast cells with the compound 48/80 and the extracts.Results:This study indicates that the chloroform, petroleum ether, and methanolic extracts were shown potent and has significant (P < 0.01 and P < 0.001) inhibitory effects on compound 48/80 induced anaphylactic reaction and mast cell activation. This compound also inhibited significantly compound 48/80 induced increased level of nitric oxide in rat peritoneal mast cells.Conclusion:We conclude from this study that the different extracts of S. potatorum seed have potent antianaphylactic activity through mast cell stabilization and inhibition of nitric oxide synthesis. The inhibitory effect of S. potatorum Linn. on release of histamine and nitric oxide protects from compound 48/80 induced anaphylactic reaction may be through blocking vasodilatation, decrease vascular resistance, hypotension and tachycardia induced by immunogenic agent used in this study.
机译：目的：采用化合物48/80诱导的过敏反应评价马兜铃种子提取物的抗过敏活性，并通过大鼠腹膜肥大细胞研究肥大细胞的稳定性。通过化合物48/80诱导的大鼠腹膜肥大细胞的肥大细胞活化和一氧化氮水平评估可能的抗过敏和肥大细胞稳定机制。材料与方法：腹膜内给予8 mg / kg引起小鼠过敏性休克在诱导过敏反应之前，将化合物48/80用化合物S.potatorum Linn处理。在给予化合物48/80前1小时口服给予种子提取物，观察每组动物的死亡率。通过将肥大细胞与化合物48/80和提取物进行预温育，可以观察到肥大细胞的稳定。结果：这项研究表明，氯仿，石油醚和甲醇提取物均显示有效且具有显着性（P <0.01和P <0.001）抑制化合物48/80引起的过敏反应和肥大细胞活化。该化合物还显着抑制化合物48/80诱导的大鼠腹膜肥大细胞中一氧化氮水平的升高。结论：我们得出的结论是，马铃薯链球菌种子的不同提取物通过肥大细胞稳定和抑制一氧化氮而具有有效的抗过敏活性。合成。马铃薯链霉菌Linn的抑制作用。组胺和一氧化氮的释放对化合物48/80引起的过敏反应的保护作用可能是通过本研究中使用的免疫原性药物诱导的阻断血管舒张，降低血管阻力，低血压和心动过速。

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