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首页> 外文期刊>Pharmacognosy Research >Evaluation of acute toxicity and hepatoprotective activity of the methanolic extract of Dichrostachys cinerea (Wight and Arn.) leaves
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Evaluation of acute toxicity and hepatoprotective activity of the methanolic extract of Dichrostachys cinerea (Wight and Arn.) leaves

机译：灰褐Dichrostachys cinerea（Wight and Arn。）叶片甲醇提取物的急性毒性和保肝活性的评估

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Background:D. cinerea are the chief source of drug compounds that are active against various ailments such as jaundice, inflammations rheumatism, fever, asthma, body ache, chest problems, toothache, ulcers, wounds, eye diseases and have an aphrodisiac property. In present study, It was aimed to test the hepatoprotective activity of the plant.Material and Methods:The methanolic extract of Dichrostachys cinerea (Mimoseae) leaves was subjected to evaluation of acute toxicity and hepatoprotective property, using albino mice and rats. The parameters for estimation of liver function, based on serum markers such as total bilirubin, total protein, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase with histopathological profile of the liver tissue, were studied consequently.Results:The methanolic extract did not show any mortality up to a dose of 3500 mg/kg body weight. The methanolic extract showed significant hepatoprotectivity. The histopathological profile of the drug-treated liver tissue demonstrated similar morphology as that of controls.Conclusions:Methanolic extract of Dichrostachys cinerea was found to have significant hepatoprotective activity.
机译：背景：D。灰质是可对抗各种疾病如黄疸，炎症性风湿病，发烧，哮喘，身体疼痛，胸部疾病，牙痛，溃疡，伤口，眼部疾病并具有壮阳作用的药物的主要来源。材料与方法：用白化病小鼠和大鼠对灰黄菊叶片的甲醇提取物进行急性毒性和保肝性能的评价。因此，根据血清标志物，如总胆红素，总蛋白，丙氨酸氨基转移酶，天冬氨酸氨基转移酶，碱性磷酸酶以及肝脏组织病理学特征，评估了估计肝功能的参数。结果：甲醇提取物未显示任何死亡率最高剂量为3500 mg / kg体重。甲醇提取物显示出显着的肝保护性。经药物处理的肝组织的组织病理学特征与对照组具有相似的形态学。结论：发现金缕梅的甲醇提取物具有显着的保肝活性。

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