• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacognosy Research >Effect of Butea monosperma Lam. leaves and bark extracts on blood glucose in streptozotocin-induced severely diabetic rats
【24h】

Effect of Butea monosperma Lam. leaves and bark extracts on blood glucose in streptozotocin-induced severely diabetic rats

机译：紫丁香林的效果。叶和树皮提取物对链脲佐菌素诱导的重度糖尿病大鼠血糖的影响

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background:Diabetes mellitus is a chronic metabolic disorder that has significant impact on the health, quality of life and life expectancy, as well as on the health care system. Butea monosperma Lam. Kuntze (Fabaceae), commonly known as palash, is widely used in the treatment of various diseases and disorders including diabetes.Materials and Methods:The present study was planned to evaluate the antidiabetic effect of aqueous extracts of B. monosperma leaves and bark in streptozotocin-induced severely diabetic rats. The animals were divided into four groups, with each consisting of six rats, viz. control, diabetic control, leaf extract-treated and bark extract-treated groups. Treatment was continued for 6 weeks. The biochemical estimations included blood glucose and serum insulin levels. Histopathology of pancreas was also performed.Results:The results indicated that both leaf and bark extracts of B. monosperma produced insignificant antihyperglycemic activity. The leaf and bark extracts reduced blood glucose to an extent of 28% and 11%, respectively. It was also evidenced that both leaf and bark extracts did not increase insulin synthesis or secretion and did not improve pancreatic architecture as reflected by the histopathologic studies.Conclusions:The findings of the study emphasize that B. monosperma does not possess significant antidiabetic activity in severe experimental diabetes at the dosage tested.
机译：背景：糖尿病是一种慢性代谢性疾病，对健康，生活质量和预期寿命以及医疗保健系统产生重大影响。紫丁香林。昆士兰（Fabaceae），通常被称为palash，广泛用于治疗包括糖尿病在内的各种疾病和疾病。材料与方法：本研究旨在评估单精子芽孢杆菌叶片和树皮的水提物在链脲佐菌素中的抗糖尿病作用。诱导的严重糖尿病大鼠。将动物分为四组，每组由六只大鼠组成。对照组，糖尿病对照组，叶提取物处理组和树皮提取物处理组。治疗持续了6周。生化评估包括血糖和血清胰岛素水平。结果：结果表明，单精子芽孢杆菌的叶和树皮提取物均未产生明显的降血糖活性。叶和树皮提取物将血糖分别降低了28％和11％。组织病理学研究还表明，叶提取物和树皮提取物均未增加胰岛素的合成或分泌，也未改善胰腺的结构。结论：研究结果强调，单精子芽孢杆菌在重度糖尿病中不具有明显的抗糖尿病活性。实验性糖尿病的测试剂量。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号