• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacognosy Research >Aerva lanata (Polpala): Its effects on the structure and function of the urinary tract
【24h】

Aerva lanata (Polpala): Its effects on the structure and function of the urinary tract

机译：Aerva lanata（Polpala）：对尿路结构和功能的影响

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Context:Aerva lanata is not prescribed for long-term use in Ayurveda as it is believed to produce structural changes in the urinary tract of the patients leading to renal failure.Aim:To investigate the toxic effects of Aerva lanata on the structure and function of urinary tract of a rat model (Sprague-Dawley rats).Settings and Design:An experimental study. Thirty male and thirty female healthy rats were randomly assigned to three groups (test groups 1, 2 and control) and administered dried infusion of A. lanata 25g/200ml (low dose), 100g/200ml (high dose) and distilled water respectively, for 30 days.Materials and Methods:Blood and urine were collected and creatinine was measured. Creatinine clearance (Ccr) and urine flow rate (UFR) of rats were determined to assess renal function. Kidneys, ureters, and bladders of rats were harvested for light microscopic (LM) studies. Electron microscopic (EM) studies were done on kidney tissues.Statistical Analysis Used:Difference in mean values of Ccr and UFR between test groups and the control group were compared statistically using independent T test. LM and EM findings of the two treated groups (T1 and T2) were statistically compared with the control group (C) using standard normal distribution.Results:Ccr and UFR of test groups were not significantly different from that of the control group. LM studies did not show any histological changes suggesting toxicity. EM, however showed significant ultra structural changes in proximal convoluted tubular epithelial cells of rats in the two test groups.Conclusion:Administration of dried Aerva lanata for a period of one month did not produce significant effects on renal function of rats. However administration for the same period caused significant ultra structural changes in the proximal convoluted tubular epithelial cells.
机译：背景：阿育吠陀不建议长期用于阿育吠陀，因为它会导致患者尿路结构改变，从而导致肾功能衰竭。大鼠模型（Sprague-Dawley大鼠）的尿路。设置与设计：一项实验研究。将30只雄性和30只雌性健康大鼠随机分为三组（测试组1、2和对照组），分别给予25.00 g / 200 ml（低剂量），100 g / 200 ml（高剂量）和蒸馏水干输液。 30天。材料与方法：收集血液和尿液，并测定肌酐。确定大鼠的肌酐清除率（Ccr）和尿流率（UFR）以评估肾功能。收获大鼠的肾脏，输尿管和膀胱用于光学显微镜（LM）研究。在肾脏组织上进行了电子显微镜（EM）研究。统计分析使用：独立T检验比较测试组和对照组的Ccr和UFR平均值差异。用标准正态分布对两个治疗组（T1和T2）的LM和EM结果与对照组（C）进行统计学比较。结果：试验组的Ccr和UFR与对照组无显着差异。 LM研究未显示任何暗示毒性的组织学变化。然而，在两个测试组中，EM显示出大鼠近端回旋肾小管上皮细胞明显的超微结构变化。结论：干燥的Aerva lanata给药1个月对大鼠的肾功能没有明显影响。然而，相同时期的给药引起近端回旋的管状上皮细胞的显着超结构变化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号