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首页> 外文期刊>Pharmacognosy Research >Antidepressant-like effects of young green barley leaf (Hordeum vulgare L.) in the mouse forced swimming test
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Antidepressant-like effects of young green barley leaf (Hordeum vulgare L.) in the mouse forced swimming test

机译：年轻的绿色大麦叶（大麦）在小鼠强迫游泳试验中的抗抑郁样作用

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Background:Young green barley leaf is one of the richest sources of antioxidants and has been widely consumed for health management in Japan. In this study, we examined whether oral administration of young green barley leaf has an antidepressant effect on the forced swimming test in mice.Materials and Methods:Mice were individually forced to swim in an open cylindrical container, one hour after oral administration of young green barley leaf (400 or 1000 mg / kg) or imipramine (100 mg / kg). Expression of mRNA for nerve growth factor (NGF), brain-derived neurotrophic factor, and glucocorticoid receptor in the brain was analyzed using real-time quantitative polymerase chain reaction (PCR).Results:There was a significant antidepressant-like effect in the forced swimming test; both 400 and 1000 mg / kg young green barley leaves, as well as the positive control imipramine (100 mg / kg), reduced the immobility duration compared to the vehicle group. The expression of mRNA for NGF detected in the hippocampus immediately after the last swimming test was higher than that in the non-swimming group (Nil). Oral administration of imipramine suppressed this increase to the level of the Nil group. Young green barley leaf (400 and 1000 mg / kg) also showed a moderate decrease in the expression of mRNA for NGF, in a dose-dependent manner.Conclusion:Oral administration of young green barley leaf is able to produce an antidepressant-like effect in the forced swimming test. Consequently it is possible that the antidepressant-like effects of the young green barley leaf are, at least in part, mediated by an inhibition of the increase in the hippocampus levels of NGF.
机译：背景：年轻的绿色大麦叶是最丰富的抗氧化剂来源之一，在日本已被广泛用于健康管理。在这项研究中，我们研究了口服青绿色大麦叶是否对小鼠的强迫游泳试验具有抗抑郁作用。材料和方法：小鼠在口服青绿色大麦后一小时被分别强迫在开放的圆柱形容器中游泳大麦叶（400或1000 mg / kg）或丙咪嗪（100 mg / kg）。实时定量聚合酶链反应（PCR）分析了神经生长因子（NGF），脑源性神经营养因子和糖皮质激素受体的mRNA表达。结果：在强迫症中有明显的抗抑郁样作用游泳测试;与媒介物组相比，400和1000 mg / kg的年轻绿色大麦叶以及阳性对照丙咪嗪（100 mg / kg）均减少了固定时间。上次游泳测试后立即在海马中检测到的NGF mRNA的表达高于非游泳组（Nil）。口服丙咪嗪可将这种增加抑制到Nil组水平。绿大麦幼叶（400和1000 mg / kg）还显示NGF mRNA的表达呈剂量依赖性的适度下降。结论：口服绿大麦幼叶能产生抗抑郁样作用在强迫游泳测试中。因此，有可能年轻的绿色大麦叶的抗抑郁样作用至少部分地由抑制NGF海马水平的增加介导。

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