...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Physiological Reports >Exposure to electronic cigarette vapors affects pulmonary and systemic expression of circadian molecular clock genes
【24h】

Exposure to electronic cigarette vapors affects pulmonary and systemic expression of circadian molecular clock genes

机译：接触电子烟蒸气会影响昼夜节律性分子时钟基因的肺和全身表达

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

E?￠????cigarette use has exploded in the past years, especially among young adults and smokers desiring to quit. While concerns are mostly based on the presence of nicotine and flavors, pulmonary effects of propylene glycol and glycerol inhalation, the main solvents of e?￠????liquid have not been thoroughly investigated. In this preclinical study, mice were exposed 2????h daily for up to 8????weeks to vapors of propylene glycol and/or glycerol generated by an e?￠????cigarette. Lung transcriptome analysis revealed it affected the expression level of genes of the circadian molecular clock, despite causing no inflammatory response. Periodical sacrifices showed that the rhythmicity of these regulatory genes was indeed altered in the lungs, but also in the liver, kidney, skeletal muscle, and brain. E?￠????cigarette exposure also altered the expression of rhythmic genes (i.e., hspa1a and hspa1b ), suggesting that alterations to the ?￠????clock genes?￠???? could translate into systemic biological alterations. This study reveals that the major solvents used in e?￠????cigarettes propylene glycol and glycerol, not nicotine or flavors, have unsuspected effects on gene expression of the molecular clock that are to be taken seriously, especially considering the fundamental role of the circadian rhythm in health and disease.
机译：过去几年中，尤其是在年轻人和渴望戒烟的吸烟者中，电子烟的使用激增。尽管关注的主要依据是尼古丁和香料的存在，丙二醇对肺部的影响和甘油的吸入，但尚未充分研究液体的主要溶剂。在这项临床前研究中，小鼠每天暴露2小时，最多8周，暴露于由电子烟产生的丙二醇和/或甘油蒸汽中。肺转录组分析显示，尽管没有引起炎症反应，但它影响了昼夜节律分子时钟基因的表达水平。定期的献祭表明，这些调节基因的节律性确实在肺中发生了改变，但在肝脏，肾脏，骨骼肌和大脑中也发生了改变。大肠杆菌的暴露也改变了节律基因（即hspa1a和hspa1b）的表达，这表明钟基因的改变。可以转化为全身性的生物学改变。这项研究表明，在电子烟，丙二醇和甘油中使用的主要溶剂，而不是尼古丁或香料，对分子钟的基因表达有意想不到的影响，应认真对待，特别是考虑到其基本作用。健康和疾病中的昼夜节律。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号