• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacognosy Research >Oxidative Stress Parameters and Erythrocyte Membrane Adenosine Triphosphatase Activities in Streptozotocin-induced Diabetic Rats Administered Aqueous Preparation of Kalanchoe Pinnata Leaves
【24h】

Oxidative Stress Parameters and Erythrocyte Membrane Adenosine Triphosphatase Activities in Streptozotocin-induced Diabetic Rats Administered Aqueous Preparation of Kalanchoe Pinnata Leaves

机译：链脲佐菌素诱导的糖尿病大鼠水提Kalanchoe pinnata叶片的氧化应激参数和红细胞膜腺苷三磷酸酶活性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Diabetes mellitus is a chronic metabolic disease that according to the World Health Organization affects more than 382 million people. The rise in diabetes mellitus coupled with the lack of an effective treatment has led many to investigate medicinal plants to identify a viable alternative. Objective: To evaluate red blood cell (RBC) membrane adenosine triphosphatase (ATPase) activities and antioxidant levels in streptozotocin-induced diabetic rats administered aqueous preparation of Kalanchoe pinnata leaves. Materials and Methods: Diabetes mellitus was induced in rats by a single administration of streptozotocin (60 mg/kg). Diabetic rats were then treated with aqueous K. pinnata preparation (three mature leaves ~ 9.96 g/70 kg body weight or about 0.14 g/kg body weight/day) for 30 days. Serum glucose, RBC membrane ATPase activities, and antioxidant levels were determined. Results: We noted weight loss and reduced food consumption in the treated diabetic group. Serum glucose levels were reduced in the treated diabetic group compared to the other groups. Superoxide dismutase activity and glutathione levels were not significantly elevated in the treated group compared to the diabetic group. However, serum catalase activity was significantly ( P 2+ ATPase activity and a nonsignificant increase in Na+/K+ ATPase activity in the RBC membrane of the treated diabetic group compared to the diabetic group. Conclusion: The consumption of aqueous preparation of K. pinnata may accrue benefits in the management of diabetes by lowering oxidative stress often associated with the disease and improving the availability of cellular magnesium through an increase in the magnesium ATPase pump in the RBC membrane for increased cellular metabolism of glucose through the glycolytic pathway. SUMMARY We noted weight loss and reduced food consumption in the diabetic rats treated with K. pinnata preparation Serum glucose levels were reduced in diabetic rats treated with K. pinnata preparation Serum catalase activity was significantly ( P 2+ ATPase activity in the RBC membranes of diabetic rats treated with K. pinnata preparation Overall, the consumption of aqueous preparation of K. pinnata lowered oxidative stress often associated with diabetes and improved availability of cellular magnesium through an increase in magnesium ATPase pump in the RBC membrane.
机译：背景：糖尿病是一种慢性代谢性疾病，据世界卫生组织称，它影响了超过3.82亿人。糖尿病的增加以及缺乏有效的治疗方法导致许多人对药用植物进行研究，以确定可行的替代方法。目的：评价链脲佐菌素诱导的糖尿病大鼠服用Kalanchoe pinnata叶片水制剂后的红细胞（RBC）膜腺苷三磷酸酶（ATPase）活性和抗氧化剂水平。材料和方法：通过单次施用链脲佐菌素（60 mg / kg）在大鼠中诱发糖尿病。然后用含水的K.pinnata制剂（三片成熟叶〜9.96g / 70kg体重或约0.14g / kg体重/天）处理糖尿病大鼠30天。测定血清葡萄糖，RBC膜ATPase活性和抗氧化剂水平。结果：我们注意到在治疗的糖尿病组中体重减轻和食物消耗减少。与其他组相比，治疗的糖尿病组的血清葡萄糖水平降低。与糖尿病组相比，治疗组的超氧化物歧化酶活性和谷胱甘肽水平没有显着升高。然而，在处理过的红细胞膜中，血清过氧化氢酶活性显着（P 2 + ATPase活性，Na + / K + ATPase活性无明显增加。结论：食用K. pinnata的水性制剂可通过降低通常与疾病相关的氧化应激并通过增加ATP镁酶来改善细胞镁的利用率，从而在糖尿病管理中获得益处。总结我们注意到在用针状K.pinnata制剂治疗的糖尿病大鼠中，体重减轻并减少了食物的摄入在用针状K.pinnata制剂治疗的糖尿病大鼠中血清葡萄糖水平降低了用针状K.pinnata制剂治疗的糖尿病大鼠的RBC膜中过氧化氢酶活性显着（P 2 + ATPase活性羽衣甘蓝的制备降低了通常与糖尿病相关的氧化应激，并通过增加RBC膜中的镁ATPase泵提高了细胞镁的利用率。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号