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首页> 外文期刊>Pharmacognosy Research >Antioxidant and Immunomodulatory Activity of Hydroalcoholic Extract and its Fractions of Leaves of Ficus benghalensis Linn.
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Antioxidant and Immunomodulatory Activity of Hydroalcoholic Extract and its Fractions of Leaves of Ficus benghalensis Linn.

机译：孟加拉榕榕叶片水醇提取物及其叶的级分的抗氧化和免疫调节活性。

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Background: Ficus benghalensis is a folk medicine indigenous plant of India. Several studies on this plant reported and focused on the biological profile of the plant. Objectives: This study is aimed to evaluate the antioxidant and immunomodulatory activity of F. benghalensis leaf extract using various in vitro screening methods of both parameters. Materials and Methods: Hydroalcoholic (FB1) extract and it's four fractions viz. n-hexane (FB2), n-butanol (FB3), chloroform (FB4), and water (FB5) of leaves of F. benghalensis investigated for their free radical scavenging activity using 1-1-diphneyl-2-picrylhydrazyl and 2, 2′-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) radicals. A dose-response curve was plotted and IC50 values were determined to assess antioxidant activity. Nitroblue tetrazolium test, phagocytosis of killed Candida albicans and candidacidal assay were carried out to assess the immunomodulatory activity. Positive non-lymphoid cell number, mean particle number of killed C. albicans , percent value of killed C. albicans by neutrophils were calculated and presented. Results: All extracts showed antioxidant and prominent immunomodulatory activity with compared to standard. Conclusions: Hydroalcoholic (FB1) extract and its four fractions viz. n-hexane (FB2), n-butanol (FB3), chloroform (FB4), and water (FB5) showed promising antioxidant and immunomodulatory activity. SUMMARY Hydroalcoholic extract and its fractions of F. benghalensis Linn exhibited different DPPH and ABTS scavenging activity in concentration dependent manner. The extract, fractions and reference antioxidants showed DPPH scavenging effect in the order of Vit-C > Quercetin > FB2 > FB1 > FB5 > FB4> FB3 and ABTS scavenging effect in the order of Vit-C > Quercetin > FB1> FB2 > FB5 > FB3> FB4. FB2 and FB3 showed promising immunomodulatory activity at all concentrations.
机译：背景：孟加拉榕是印度的一种民间草药。关于该植物的一些研究报道并集中于该植物的生物学特征。目的：本研究旨在使用两种参数的多种体外筛选方法来评估孟加拉镰刀菌叶片提取物的抗氧化和免疫调节活性。材料和方法：水醇（FB1）提取物，它是四个部分，即。使用1-1-二萘基-2-吡啶并和2，研究了孟加拉F叶片的正己烷（FB2），正丁醇（FB3），氯仿（FB4）和水（FB5）清除自由基的活性。 2′-叠氮基双（3-乙基苯并噻唑啉-6-磺酸）基团。绘制剂量-反应曲线并确定IC 50 值以评估抗氧化活性。进行了硝基蓝四唑鎓测试，杀死的白色念珠菌的吞噬作用和念珠菌酸测定以评估免疫调节活性。计算并给出了阳性非淋巴样细胞数，被中性粒细胞杀死的白色念珠菌的平均颗粒数，被杀死的白色念珠菌的百分比值。结果：与标准品相比，所有提取物均具有抗氧化和突出的免疫调节活性。结论：水醇提取物及其四个馏分。正己烷（FB2），正丁醇（FB3），氯仿（FB4）和水（FB5）显示出有希望的抗氧化和免疫调节活性。发明内容本发明的水乙醇提取物及其部分分离物以浓度依赖性方式表现出不同的DPPH和ABTS清除活性。提取物，馏分和参比抗氧化剂按Vit-C>槲皮素> FB2> FB1> FB5> FB4> FB3的顺序显示DPPH清除效果，而Vit-C>槲皮素> FB1> FB2> FB5>的顺序显示ABPH清除效果。 FB3> FB4。 FB2和FB3在所有浓度下均显示出有希望的免疫调节活性。

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