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首页> 外文期刊>Pharmacognosy Research >Antimicrobial, Anti-inflammatory and Antioxidant Activities of Jatropha multifida L. (Euphorbiaceae)
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Antimicrobial, Anti-inflammatory and Antioxidant Activities of Jatropha multifida L. (Euphorbiaceae)

机译：麻风树麻风树的抗微生物，抗炎和抗氧化活性

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Background: Jatropha multifida is used in Togolease folk medicine for the healing of chronic wounds. Objective: This study aims to investigate antibacterial, anti-inflammatory and antioxidant activities of the leaves ethanolic extract. Materials and Methods: The antimicrobial activity was assayed by National Committee for Clinical Laboratory Standards broth microdilution method on strains of Staphylococcus aureus and Pseudomoas aeruginosa isolated from wounds, whereas the anti-inflammatory activity was performed by carrageenan and histamine induced paw edema method in rat modele. The 2, 2-diphenyl-1picrylhydrazyl (DPPH) free radical scavenging and ferric reducing antioxidant power (FRAP) were used for the antioxidant activity. Results: The antibacterial assay showed an in vitro growth inhibition of P. aeruginosa and S. aureus in dose-dependent manner, with minimum inhibitory concentration values ranging from 2.5 to 3.12 mg/mL for S. aureus and from 6.25 to 12.5 mg/mL for P. aeruginosa . The maximum paw anti-inflammatory effect occurred after 3 and 5 h administration of histamine and carrageenan, respectively. The DPPH radical scavenging and the FRAP assays yielded weak antioxidant activity. Conclusion: J. multifida possesses antibacterial and anti-inflammatory activities that could justify the use of the plant for the treatment of wounds in the folk medicine. SUMMARY Antibacterial on germs isolated from wound, anti-inflammatory and antioxidant activities of Jatropha multifida were assayed by NCCLS broth method, carrageenan and histamine, DPPH and FRAP respectively. The results indicated that Jatropha multifida possesses antibacterial and anti-inflammatory and weak antioxidant activities that could justify its use for the treatment of wounds in the folk medicine.
机译：背景：麻风树麻风树在多哥（Togolease）民间医学中用于治疗慢性伤口。目的：本研究旨在研究叶片乙醇提取物的抗菌，抗炎和抗氧化活性。材料与方法：采用美国国家临床实验室标准委员会肉汤微量稀释法对从伤口分离出的金黄色葡萄球菌和铜绿假单胞菌菌株进行抗菌活性测定，而角叉菜胶和组胺诱导的爪水肿法对大鼠模型进行抗炎活性测定。 。 2，2-二苯基-1picylhydrazyl（DPPH）自由基清除和铁还原抗氧化能力（FRAP）用于抗氧化活性。结果：抗菌测定显示了铜绿假单胞菌和金黄色葡萄球菌的体外生长抑制作用呈剂量依赖性，最小抑制浓度范围为金黄色葡萄球菌2.5到3.12 mg / mL，6.25到12.5 mg / mL为铜绿假单胞菌。分别给予组胺和角叉菜胶3和5小时后，最大的爪子抗炎作用发生。 DPPH自由基清除和FRAP分析产生弱的抗氧化活性。结论：多重假单胞菌具有抗菌和消炎活性，可以证明该植物在民间医学中用于治疗伤口的合理性。发明内容通过NCCLS肉汤法，角叉菜胶和组胺，DPPH和FRAP分别测定从伤口分离的细菌的抗菌性，麻风树的消炎和抗氧化活性。结果表明，麻风树具有抗菌，抗炎和抗氧化活性弱，可以证明其在民间医学伤口治疗中的应用。

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