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首页> 外文期刊>Pharmacognosy Research >Methanolic Extract of Curcuma caesia Roxb. Prevents the Toxicity Caused by Cyclophosphamide to Bone Marrow Cells, Liver and Kidney of Mice
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Methanolic Extract of Curcuma caesia Roxb. Prevents the Toxicity Caused by Cyclophosphamide to Bone Marrow Cells, Liver and Kidney of Mice

机译：姜黄中药渣提取物的甲醇提取物。预防环磷酰胺对小鼠骨髓细胞，肝脏和肾脏的毒性

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Introduction: With an ever increasing cause of cancer, it has been recommended to treat with conventional drugs, however because of the side effects caused by the conventional drugs, the research on medicinal plants has been intensified due to their less adverse and toxic effects. Objectives: The primary objective of the present study was to evaluate the protective effect of the medicinal plant Curcuma caesia Roxb. against free radicals ABTS+ and O2-. Also it was aimed to evaluate the protective effect of C.caesia Roxb. against the chemotherapeutic drug Cyclophosphamide and its side effects in liver and kidney. Methods: The rhizomes of the plant was extracted with methanol through soxhlet and its antioxidant activity was tested against ABTS+ and O2-. For antigenotoxic studies, animals were divided into eight groups and micronucleus assay was employed and for biochemical analysis serum sample was collected from the blood and SGOT, SGPT analysis was performed. Also the biochemical analysis was performed from both the liver and kidney. Results: The methanolic extract of Curcuma caesia Roxb. was found to scavenge the free radicals ABTS+ and O2-. the micronuclei formation was found to be increased in the positive control group as compared to the negative control group significantly ( P <0.002) however increase in the number of micronuclei was found to be decrease with the pretreatment of the extract at different concentrations significantly as compared to the negative control groups ( P <0.01, P <0.005, P <0.001). The increased level of serum SGPT and SGOT as well as peroxidation level in both liver and kidney due to treatment of cyclophosphamide was also found to be decreased with the pretreatment of the extract significantly as compared to the positive control groups. There was decreased in the level of endogenous antioxidant such as GSH and GR in the positive control group however decreased level of GSH and GR was found to be increased with the pretreatment of the methanolic extract of C. caesia Roxb. Conclusion: The present study suggested that the methanolic extract of C. caesia Roxb has not shown any genotoxicity and reduces the genotoxicity caused by cyclophosphamide. It was also to have the protective effects against the liver and kidney. So it could be provided as one of the herbal supplementation in chemoprevention of CP to ameliorate the side effects of it. SUMMARY Cancer is characterized by uncontrolled growth of cells and much research has been done for the past several years from various disciplines for the treatment of cancer but till now no therapy has been discovered. Treatment of cancer with chemotherapeutic drugs has been suggested to prevent cancer cells however they are often limited with their toxicity to normal cells. Therefore it has been suggested that the supplementation of medicinal plants which are rich source of antioxidants can decrease the toxic effect caused by chemotherapeutic drugs. Curcuma caesia Roxb is a medicinal plant which has high antioxidant activity, as per present study, methanolic extract of Curcuma caesia Roxb prevents the toxicity caused by cyclophosphosphamide (chemotherapeutic drug) in bone marrow cells by reducing the micronuclei formation; it also prevents the hepatotoxicity and nephrotoxicity caused by cyclophosphamide, so it can be used as a supplement in cancer treatment with cyclophosphamide.
机译：简介：随着致癌原因的不断增加，建议使用常规药物进行治疗，但是由于常规药物引起的副作用，药用植物的研究由于其不良作用和毒性较小而得到了加强。目的：本研究的主要目的是评估药用植物莪术（Cercuma caesia Roxb）的保护作用。对抗自由基ABTS + 和O 2 -。它还旨在评估C.caesia Roxb的保护作用。化疗药物环磷酰胺及其在肝脏和肾脏中的副作用。方法：用索氏提取法用甲醇提取植物的根茎，测定其抗ABTS + 和O 2 -的抗氧化活性。为了进行抗原毒性研究，将动物分为八组并进行微核试验，并从血液和SGOT中收集血清样品进行生化分析，然后进行SGPT分析。还从肝脏和肾脏进行了生化分析。结果：姜黄药材的甲醇提取物。被发现清除自由基ABTS + 和O 2 -。与阴性对照组相比，阳性对照组中的微核形成明显增加（P <0.002），但是与不同浓度的提取物预处理相比，微核数量的增加明显减少阴性对照组（P <0.01，P <0.005，P <0.001）。与阳性对照组相比，用提取物的预处理还发现，由于环磷酰胺的治疗，血清SGPT和SGOT的水平升高以及肝脏和肾脏中的过氧化水平也明显降低。阳性对照组中内源性抗氧化剂如GSH和GR的水平降低，但是发现通过预处理C. caesia Roxb的甲醇提取物，GSH和GR的降低水平会增加。结论：本研究表明，C.caesia Roxb的甲醇提取物未显示任何遗传毒性，并降低了由环磷酰胺引起的遗传毒性。它还具有对肝脏和肾脏的保护作用。因此可以作为化学预防CP的草药补充剂之一，以减轻其副作用。发明内容癌症的特征在于细胞的不受控制的生长，并且在过去的几年中，已经进行了来自各个学科的许多研究以治疗癌症，但是直到现在还没有发现疗法。已经建议用化学治疗药物治疗癌症可以预防癌细胞，但是它们通常对正常细胞的毒性受到限制。因此，已经提出，补充富含抗氧化剂的药用植物可以降低由化学治疗药物引起的毒性作用。姜黄开胃菜是具有高抗氧化活性的药用植物，根据目前的研究，姜黄开胃菜的甲醇提取物通过减少微核的形成来防止环磷酰胺（化疗药）对骨髓细胞的毒性。它还可以防止环磷酰胺引起的肝毒性和肾毒性，因此可以用作环磷酰胺治疗癌症的补充剂。

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