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首页> 外文期刊>Pharmacognosy Research >Chromatographic Profiling of Ellagic Acid in Woodfordia fruticosa Flowers and their Gastroprotective Potential in Ethanol-induced Ulcers in Rats
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Chromatographic Profiling of Ellagic Acid in Woodfordia fruticosa Flowers and their Gastroprotective Potential in Ethanol-induced Ulcers in Rats

机译：桔梗花中鞣花酸的色谱分析及其在乙醇诱发的大鼠溃疡中的胃保护作用

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Background: Woodfordia fruticosa , a plant of Indian origin, is extensively used in folk medicine for the treatment of various ailments. Objective: The aim of the present study was to standardize the flowers of W. fruticosa , Kurz ( Lythraceae ), an important plant of Indian origin and explore the chemical constituents contributing to its anti-ulcer activity. Materials and Methods: High-performance thin layer chromatography (HPTLC) and high-performance liquid chromatography (HPLC) profiling of the three samples of W. fruticosa flowers purchased from three different markets was done using ellagic acid as the biomarker. Two doses of the aqueous extract of the W. fruticosa (AEWF) flowers were evaluated for anti-ulcer activity by ethanol-induced ulcer model in Wistar albino rats. Omeprazole was used as the positive control. The parameters used for the assessment of the anti-ulcer potential were total titratable acidity (TTA), ulcer index, and percentage protection. Results: The HPTLC and HPLC studies confirmed the presence of ellagic acid in all the three drug samples. The AEWF showed significant reduction in terms of TTA at both doses of 100 mg/kg and 200 mg/kg. The gastroprotection indicated by a lower ulcer index and higher percentage protection was significant for 200 mg/kg dose of AEWF, better than the protection afforded by omeprazole (10 mg/kg). Conclusion: The chromatographic profiling and the anti-ulcer studies served as an efficient tool in the characterization of ellagic acid as an important biomarker for the flowers of W. fruticosa and a probable contributor to the gastroprotective capacity of the drug. The bioactivity studies further supported the traditional use of W. fruticosa in the treatment of ulcers. SUMMARY HPTLC & HPLC fingerprinting of W. fruticosa using ellagic acid as a biomarker. Evaluation of W. fruticosa for gastroprotection potential in ethanol induced gastric ulcer in rats model. Aqueous extract of the drug showed better gastroprotection than the standard drug omeprazole at a dose of 200 mg/kg.
机译：背景：Woodfordia fruticosa是印度血统的一种植物，被广泛用于民间医学中以治疗各种疾病。目的：本研究的目的是标准化印度起源的重要植物苦瓜（Kurz（Lythraceae））的花朵，并探索有助于其抗溃疡活性的化学成分。材料和方法：使用鞣花酸作为生物标记物，对从三个不同市场购买的三株金丝桃花进行了高效薄层色谱（HPTLC）和高效液相色谱（HPLC）分析。通过Wistar albino大鼠的乙醇诱导的溃疡模型评估了两剂金丝桃的水提取物（AEWF）的抗溃疡活性。奥美拉唑用作阳性对照。用于评估抗溃疡潜力的参数是总可滴定酸度（TTA），溃疡指数和保护百分率。结果：HPTLC和HPLC研究证实了所有三种药物样品中均存在鞣花酸。 AEWF在100 mg / kg和200 mg / kg两种剂量下均显示出TTA的显着降低。对于200 mg / kg剂量的AEWF，较低的溃疡指数和较高的保护百分比表示的胃保护作用显着，优于奥美拉唑（10 mg / kg）提供的保护作用。结论：色谱分析和抗溃疡研究可作为鞣花酸表征的有效工具，鞣花酸是紫苏花的重要生物标志物，并且可能是该药物的胃保护能力的贡献者。生物活性研究进一步支持了金丝桃原虫在溃疡治疗中的传统用途。总结使用鞣花酸作为生物标记物，对金黄色葡萄球菌的HPTLC和HPLC指纹图谱。评价金银花对大鼠乙醇诱发胃溃疡的胃保护作用。该药物的水提取物在200 mg / kg的剂量下比标准药物奥美拉唑具有更好的胃保护作用。

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