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首页> 外文期刊>Pharmacognosy Research >Development, Characterization, and Evaluation of Hepatoprotective Effect of Abutilon indicum and Piper longum Phytosomes
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Development, Characterization, and Evaluation of Hepatoprotective Effect of Abutilon indicum and Piper longum Phytosomes

机译：Ab麻和长Pipe植物脂质体的保肝作用的开发，表征和评价

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Background: Evidences from ethnopharmacological practices have shown that combination of Abutilon indicum and Piper longum are traditionally used to treat symptoms of the liver disorder. The hypothesis is phytosomes of a combination of both crude drug extract will be more effective and safe as hepatoprotective agent. Aim: Present work is aimed at development and characterization of phytosomes containing ethanolic extract of both drugs to meet the need for better effectiveness and safety. Materials and Methods: Phytosomes were formulated by using Indena's patented process. Characterization involved following parameters: Particle size determination, percentage yield, entrapment efficiency, differential scanning calorimetry, scanning electron microscope, fourier transform infrared spectroscopy, and high performance thin liquid chromatography. Liver damage was induced in adult Charles foster rats (150 ± 10 g) with CCl4 in olive oil (1:1 v/v, i.p) 1 ml/kg once daily for 7 days. LIV 52 (1 ml/kg per oral [p.o]), ethanolic extract of A. indicum and P. longum combination (100, 200, and 400 mg/kg p.o) and phytosomes (100 mg/kg p.o.) was given 3 days prior to CCl4 administration. Estimation of liver marker enzymes and histopathological studies were done. Result was analyzed by using (analysis of variance) followed by Student-Newman–Keuls test. Result: Combined extract has shown hepatoprotective activity but phytosomal formulation has more potent hepatoprotective effect on CCl4 induced liver toxicity at very low dose comparative to a higher dose of combined extract. Conclusion: Novel approach for herbal drug delivery is more prominent than conventional which improves bioavailability of polar extract and also patient compliance. SUMMARY Standardised ethanolic extract of leaves of abutilon indicum and piper longum fruits by microwave assisted extraction was used for phytosomal complex formation and phytosomal complex was characterised by various parameters and finally the hepatoprotective activity of phytosomes and crude extract was evaluated by different biochemical markers and histopathological study. Abbreviations Used: DSC: Differential scanning calorimetry, SEM: Scanning electron microscope, FTIR: Fourier transform infrared spectroscopy, HPTLC: High performance thin liquid chromatography, p.o: Per oral, A. indicum : Abutilon indicum , P. longum : Piper longum .
机译：背景：来自民族药理学实践的证据表明，传统上将Abutilon indicum和Piper longum组合用于治疗肝脏疾病的症状。假说是将两种粗体提取物结合在一起的植物体作为肝保护剂会更有效和安全。目的：目前的工作旨在开发和表征包含两种药物乙醇提取物的植物体，以满足对更高功效和安全性的需求。材料和方法：使用Indena的专利方法配制了脂质体。表征涉及以下参数：粒径测定，百分收率，包封率，差示扫描量热法，扫描电子显微镜，傅立叶变换红外光谱法和高效稀液相色谱法。每天用1 ml / kg的CCl 4 在橄榄油中的CCl 4 诱导成年Charles寄养大鼠（150±10 g）肝损伤，每天一次，共7天。服用LIV 52（口服口服1 ml / kg），印度梗曲霉和长青假单胞菌组合的乙醇提取物（100、200和400 mg / kg po）和植物小体（100 mg / kg po）在使用CCl 4 之前。进行了肝标志物酶的估计和组织病理学研究。通过使用（方差分析），然后进行Student-Newman-Keuls检验来分析结果。结果：联合提取物具有保肝活性，但与高剂量联合提取物相比，低剂量的植物体制剂对CCl 4 诱导的肝毒性具有更强的肝保护作用。结论：新的草药给药方法比常规方法更为突出，可提高极性提取物的生物利用度并提高患者依从性。总结用微波辅助提取的Standardized麻和pipe的叶片标准乙醇提取物用于植物体复合物的形成，并通过多种参数表征植物体复合物，最后通过不同的生化指标和组织病理学研究评价了植物体和粗提物的保肝活性。 。所用的缩写：DSC：差示扫描量热法，SEM：扫描电子显微镜，FTIR：傅里叶变换红外光谱，HPTLC：高效稀液相色谱，p.o：口服，A. indicum：印度Ab麻，P. longum：Piper longum。

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