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首页> 外文期刊>Pharmacogenomics and Personalized Medicine >Do CYP2C19 and ABCB1 gene polymorphisms and low CYP3A4 isoenzyme activity have an impact on stent implantation complications in acute coronary syndrome patients?
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Do CYP2C19 and ABCB1 gene polymorphisms and low CYP3A4 isoenzyme activity have an impact on stent implantation complications in acute coronary syndrome patients?

机译：CYP2C19 和 ABCB1 基因多态性和低CYP3A4同工酶活性对急性冠脉综合征患者的支架植入并发症有影响吗？

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Aim: The aim of this study was to determine the impact of CYP2C19 and ABCB1 gene polymorphisms and CYP3A4 isoenzyme activity on stent implantation complications among patients with an acute coronary syndrome (ACS) who underwent percutaneous coronary intervention (PCI). Patients and methods: Seventy-six patients (median age 63, range 37–91 years) with an ACS who underwent PCI were screened for CYP2C19 and ABCB1 gene polymorphisms with real-time polymerase chain reaction: CYP2C19*2 , CYP2C19*17 , and ABCB1 3435 . CYP3A4 isoenzyme activity was determined by urine cortisol and 6-beta-hydroxycortisol levels. Stent implantation complications such as stent thrombosis ( n =2) and restenosis ( n =1) were observed among drug-eluting stent recipients. Results: Low mean 6-beta-hydroxycortisol/cortisol ratio is indicative of impaired CYP3A4 activity and was associated with higher risk of thrombosis ( β coefficient=0.022, SE 0.009, p =0.021 in the linear regression model). The increase in the length of the implanted stent was associated with higher risk of restenosis ( β coefficient=0.006, SE=0.002, p =0.001 in the linear regression model). The presence of the CYP2C19*2 polymorphism did not affect the incidence of stent thrombosis ( β coefficient=?1.626, SE=1.449, p =0.262 in the logistic regression model), nor did the CYP2C19*17 ( β coefficient=?0.907, SE=1.438, p =0.528 in the logistic regression model) and ABCB1 3435 polymorphisms ( β coefficient=1.270, SE=1.442, p =0.378 in the logistic regression model). Conclusion: We did not find evidence that the presence of CYP2C19*2 , CYP2C19*17 , and ABCB1 3435 polymorphisms may jeopardize the safety of stent implantation in patients with an ACS. Patients with low CYP3A4 isoenzyme activity may have increased risk of stent thrombosis.
机译：目的：本研究的目的是确定CYP2C19和ABCB1基因多态性以及CYP3A4同工酶活性对接受经皮冠状动脉介入治疗（PCI）的急性冠脉综合征（ACS）患者支架植入并发症的影响。患者和方法：对76例接受PCI的ACS患者（中位年龄63岁，年龄37-91岁）进行了CYP2C19和ABCB1基因多态性的实时聚合酶链反应筛查：CYP2C19 * 2，CYP2C19 * 17和ABCB1 3435。 CYP3A4同工酶活性由尿皮质醇和6-β-羟基皮质醇水平确定。在药物洗脱支架接受者中观察到支架植入并发症，例如支架血栓形成（n = 2）和再狭窄（n = 1）。结果：6-β-羟基皮质醇/皮质醇平均平均值低表明CYP3A4活性受损，并与较高的血栓形成风险相关（线性回归模型中β系数= 0.022，SE0.00，p = 0.021）。植入支架长度的增加与再狭窄的风险较高相关（在线性回归模型中，β系数= 0.006，SE = 0.002，p = 0.001）。 CYP2C19 * 2多态性的存在对支架血栓形成的发生率没有影响（在Logistic回归模型中，β系数=？1.626，SE = 1.449，p = 0.262），CYP2C19 * 17（β系数=？0.907， SE = 1.438，在Logistic回归模型中p = 0.528）和ABCB1 3435多态性（在Logistic回归模型中β系数= 1.270，SE = 1.442，p = 0.378）。结论：我们没有发现证据表明CYP2C19 * 2，CYP2C19 * 17和ABCB1 3435基因多态性的存在可能危及ACS患者支架植入的安全性。 CYP3A4同工酶活性低的患者可能发生支架血栓的风险增加。

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