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Anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. leaves

机译：紫茉莉水提取物的抗炎活性。树叶

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Background:Theobjective of the present study was to evaluate the anti-inflammatory activity of aqueous extract of Mirabilis jalapa Linn. (MJL)(Nyctaginaceae) leaves for scientific validation of the folklore claim of the plant. The leaves are used as traditional folk medicine in the south of Brazil to treat inflammatory and painful diseases. Cosmetic or dermo-pharmaceutical compositions containing MJL are claimed to be useful against inflammation and dry skin.Methods:Aqueous extract of the leaves was prepared by cold maceration.Results:The anti-inflammatory activity was evaluated using carrageenan and formalin-induced paw edema models in Wistar albino rats. The anti-inflammatory activity was found to be dose dependent in carrageenan-induced paw edema model. The aqueous extract has shown significant (P < 0.05) inhibition of paw oedema, 37.5% and 54.0% on 4 th hour at the doses of 200 and 400 mg/kg, respectively. Similar pattern of paw edema inhibition was seen in formalin-induced paw edema model. The maximum percentage inhibition in paw edema was 32.9% and 43.0% on 4 th day at the doses of 200 and 400 mg/kg, respectively.Conclusion:The results of present study demonstrate that aqueous extract of the leaves possess significant (P < 0.05) anti-inflammatory potential.
机译：背景：本研究的目的是评估紫茉莉水提取物的抗炎活性。 （MJL）（Nyctaginaceae）叶子用于科学验证该植物的民间传说主张。叶子在巴西南部被用作传统民间药物，用于治疗炎性和疼痛性疾病。据称含有MJL的化妆品或皮肤药物组合物可有效抵抗炎症和皮肤干燥。方法：通过冷浸法制备叶片的水提取物。结果：使用角叉菜胶和福尔马林诱发的爪水肿模型评估其抗炎活性。在Wistar白化病大鼠中。在角叉菜胶诱导的爪水肿模型中发现抗炎活性与剂量有关。水提取物在200和400 mg / kg的剂量下第4小时分别显示出显着（P <0.05）的爪水肿抑制作用，分别为37.5％和54.0％。在福尔马林诱导的爪水肿模型中可以看到类似的爪水肿抑制模式。剂量为200和400 mg / kg时，第4天对爪水肿的最大抑制百分比分别为32.9％和43.0％。结论：本研究结果表明，叶片的水提物具有显着的（P <0.05 ）抗炎潜力。

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