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首页> 外文期刊>Pharmacological reports: PR >Pharmacokinetic interaction after joint administration of zinc and imipramine in forced swim test in mice.
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Pharmacokinetic interaction after joint administration of zinc and imipramine in forced swim test in mice.

机译：在小鼠强迫游泳试验中联合施用锌和丙咪嗪后，药代动力学相互作用。

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Recent preclinical and clinical data indicate beneficial role of zinc in the antidepressant treatment. To evaluate the mechanism of interaction between zinc and antidepressants, in the present study we examined the brain zinc, imipramine and desipramine concentrations in mice treated with combinations of zinc and imipramine and subjected to the forced swim test. We have chosen doses of zinc (10 mg/kg) and imipramine (15 mg/kg) which we have previously found to be ineffective in the forced swim test when given alone. However, when administered jointly, a significant reduction in the immobility time in this test was demonstrated. In the present study, we demonstrated a significant ca. 60% reduction in the brain desipramine and non-significant reduction (ca. 40%) in brain imipramine concentrations in the group of animals treated with zinc plus imipramine compared with animals treated with imipramine alone. The brain zinc concentration in the zinc plus imipramine group was reduced when compared with the group treated with zinc or imipramine alone. Since there was no increase in brain imipramine/desipramine or zinc brain concentration after combined zinc and imipramine treatment, the data suggest that pharmacodynamic rather than pharmacokinetic interaction between zinc and imipramine is responsible for behavioral effect in the forced swim test.
机译：最近的临床前和临床数据表明锌在抗抑郁药治疗中具有有益作用。为了评估锌与抗抑郁药之间相互作用的机制，在本研究中，我们检查了用锌和丙咪嗪组合治疗并进行强迫游泳试验的小鼠的大脑中锌，丙咪嗪和地昔帕明的浓度。我们选择了锌（10 mg / kg）和丙咪嗪（15 mg / kg）的剂量，此前我们发现单独使用这些剂量在强迫游泳试验中无效。然而，当联合给药时，在该测试中证明了固定时间的显着减少。在本研究中，我们证明了一个重要的约。与单独使用丙咪嗪治疗的动物相比，用锌加丙咪嗪治疗的动物组的脑中desipramine降低了60％，大脑中的imipramine浓度没有显着降低（约40％）。与单独使用锌或丙咪嗪治疗的组相比，锌加丙咪嗪组的脑锌浓度降低。由于锌和丙咪嗪联合治疗后脑中丙咪嗪/地昔帕明或锌的大脑浓度没有增加，因此数据表明锌和丙咪嗪之间的药效相互作用而非药代动力学相互作用是强迫游泳试验中行为行为的原因。

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