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首页> 外文期刊>Physiological Reports >Mouse ECG findings in aging, with conduction system affecting drugs and in cardiac pathologies: Development and validation of ECG analysis algorithm in mice
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Mouse ECG findings in aging, with conduction system affecting drugs and in cardiac pathologies: Development and validation of ECG analysis algorithm in mice

机译：小鼠ECG在衰老，传导系统影响药物和心脏疾病中的发现：小鼠ECG分析算法的开发和验证

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AbstractMouse models are extremely important in studying cardiac pathologies and related electrophysiology, but very few mouse ECG analysis programs are readily available. Therefore, a mouse ECG analysis algorithm was developed and validated. Surface ECG (lead II) was acquired during transthoracic echocardiography from C57Bl/6J mice under isoflurane anesthesia. The effect of aging was studied in young (2–3 months), middle-aged (14 months) and old (20–24 months) mice. The ECG changes associated with pharmacological interventions and common cardiac pathologies, that is, acute myocardial infarction (AMI) and progressive left ventricular hypertrophy (LVH), were studied. The ECG raw data were analyzed with an in-house ECG analysis program, modified specially for mouse ECG. Aging led to increases in P-wave duration, atrioventricular conduction time (PQ interval), and intraventricular conduction time (QRS complex width), while the R-wave amplitude decreased. In addition, the prevalence of arrhythmias increased during aging. Anticholinergic atropine shortened PQ time, and beta blocker metoprolol and calcium-channel blocker verapamil increased PQ interval and decreased heart rate. The ECG changes after AMI included early JT elevation, development of Q waves, decreased R-wave amplitude, and later changes in JT/T segment. In progressive LVH model, QRS complex width was increased at 2 and especially 4 weeks timepoint, and also repolarization abnormalities were seen. Aging, drugs, AMI, and LVH led to similar ECG changes in mice as seen in humans, which could be reliably detected with this new algorithm. The developed method will be very useful for studies on cardiovascular diseases in mice.
机译：摘要小鼠模型在研究心脏病理学和相关的电生理学方面非常重要，但是很少有小鼠心电图分析程序可供使用。因此，开发并验证了鼠标ECG分析算法。在异氟烷麻醉下经胸超声心动图检查时从C57Bl / 6J小鼠获取表面ECG（导联II）。在年轻（2-3月），中年（14个月）和老年（20-24个月）小鼠中研究了衰老的影响。研究了与药理学干预和常见心脏病相关的ECG变化，即急性心肌梗塞（AMI）和进行性左心室肥大（LVH）。使用内部ECG分析程序分析ECG原始数据，该程序专门针对鼠标ECG进行了修改。衰老导致P波持续时间，房室传导时间（PQ间隔）和脑室内传导时间（QRS复数宽度）增加，而R波幅度降低。另外，在衰老期间心律不齐的患病率增加。抗胆碱能的阿托品可缩短PQ时间，β阻滞剂美托洛尔和钙通道阻滞剂维拉帕米可延长PQ间隔并降低心率。 AMI后的ECG变化包括早期JT升高，Q波发展，R波振幅降低以及JT / T段的后期变化。在进行性LVH模型中，QRS复合体宽度在2周，尤其是4周的时间点增加，并且还观察到复极化异常。衰老，药物，AMI和LVH导致了与人类相似的小鼠ECG变化，这种新算法可以可靠地检测到这种变化。所开发的方法对于小鼠心血管疾病的研究将非常有用。

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