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首页> 外文期刊>Physiological Reports >Individual differences in physiologic measures are stable across repeated exposures to total sleep deprivation
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Individual differences in physiologic measures are stable across repeated exposures to total sleep deprivation

机译：在反复暴露于完全睡眠剥夺的情况下，生理指标的个体差异是稳定的

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AbstractSome individuals show severe cognitive impairment when sleep deprived, whereas others are able to maintain a high level of performance. Such differences are stable and trait-like, but it is not clear whether these findings generalize to physiologic responses to sleep loss. Here, we analyzed individual differences in behavioral and physiologic measures in healthy ethnic-Chinese male volunteers (n = 12; aged 22–30 years) who were kept awake for at least 26 h in a controlled laboratory environment on two separate occasions. Every 2 h, sustained attention performance was assessed using a 10-min psychomotor vigilance task (PVT), and sleepiness was estimated objectively by determining percentage eyelid closure over the pupil over time (PERCLOS) and blink rate. Between-subject differences in heart rate and its variability, and electroencephalogram (EEG) spectral power were also analyzed during each PVT. To assess stability of individual differences, intraclass correlation coefficients (ICC) were determined using variance components analysis. Consistent with previous work, individual differences in PVT performance were reproducible across study visits, as were baseline sleep measures prior to sleep deprivation. In addition, stable individual differences were observed during sleep deprivation for PERCLOS, blink rate, heart rate and its variability, and EEG spectral power in the alpha frequency band, even after adjusting for baseline differences in these measures (range, ICC = 0.67–0.91). These findings establish that changes in ocular, ECG, and EEG signals are highly reproducible across a night of sleep deprivation, hence raising the possibility that, similar to behavioral measures, physiologic responses to sleep loss are trait-like.
机译：摘要一些人在睡眠不足时表现出严重的认知障碍，而其他人则能够保持较高的表现水平。这种差异是稳定的并且是特质的，但是尚不清楚这些发现是否能概括为对睡眠丧失的生理反应。在这里，我们分析了健康的华裔男性志愿者（n = 12; 22至30岁）在行为上和行为上的个体差异，这些志愿者分别在受控实验室环境中两次醒来至少26小时。每隔2小时，使用10分钟的精神运动警惕任务（PVT）评估持续注意力表现，并通过确定随时间变化的瞳孔眼睑闭合百分率（PERCLOS）和眨眼率来客观评估嗜睡程度。在每次PVT期间，还分析了受试者之间心率及其变异性的差异以及脑电图（EEG）频谱功率。为了评估个体差异的稳定性，使用方差成分分析确定组内相关系数（ICC）。与以前的工作一致，PVT表现的个体差异在研究访视之间可重现，睡眠剥夺前的基线睡眠指标也是如此。此外，即使在调整了这些指标的基线差异之后，在剥夺睡眠期间，PERCLOS，眨眼率，心率及其变异性和EEG频谱功率也观察到稳定的个体差异（范围，ICC = 0.67-0.91 ）。这些发现表明，在整个睡眠不足的夜晚中，眼，心电图和脑电信号的变化可高度重现，因此增加了对行为丧失的生理反应类似于性状的可能性。

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