• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Physical Review X >Discriminatory Proofreading Regimes in Nonequilibrium Systems
【24h】

Discriminatory Proofreading Regimes in Nonequilibrium Systems

机译：非平衡系统中的歧视性校对制度

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We use ideas from kinetic proofreading, an error-correcting mechanism in biology, to identify new kinetic regimes in nonequilibrium systems. These regimes are defined by the sensitivity of the occupancy of a state of the system to a change in its energy. In biological contexts, higher sensitivity corresponds to stronger discrimination between molecular substrates with different energetics competing in the same reaction. We study this discriminatory ability in systems with discrete states that are connected by a general network of transitions. We find multiple regimes of different discriminatory ability when the energy of a given state of the network is varied. Interestingly, the occupancy of the state can even increase with its energy, corresponding to an “antiproofreading” regime. The number and properties of such discriminatory regimes are limited by the topology of the network. Finally, we find that discriminatory regimes can be changed without modifying any “hard-wired” structural aspects of the system but rather by simply changing external chemical potentials.
机译：我们使用动力学校对方法（生物学中的纠错机制）的思想来确定非平衡系统中的新动力学方法。这些状态由系统状态的占用对其能量变化的敏感性定义。在生物学环境中，较高的灵敏度对应于在同一反应中竞争的具有不同能量的分子底物之间的较强区分。我们研究了具有离散状态的系统中的这种区分能力，这些状态通过通用的过渡网络连接。当网络的给定状态的能量变化时，我们发现具有不同区分能力的多个状态。有趣的是，国家的占有率甚至会随着其能量的增加而增加，这对应于“反校对”制度。这种歧视性制度的数量和性质受到网络拓扑结构的限制。最后，我们发现可以更改歧视性制度而无需修改系统的任何“硬连线”结构方面，而只需更改外部化学势即可。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号