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首页> 外文期刊>Physiological Reports >Differences in oxidative metabolism modulation induced by ischemia/reperfusion between trained and untrained individuals assessed by NIRS
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Differences in oxidative metabolism modulation induced by ischemia/reperfusion between trained and untrained individuals assessed by NIRS

机译：通过NIRS评估训练有素和未经训练的个体之间由缺血/再灌注引起的氧化代谢调节的差异

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Endurance training is associated with skeletal muscle adaptations that regulate the oxidative metabolism during ischemia/reperfusion. The aim of this study was to noninvasively assess in????vivo differences in the oxidative metabolism activity during ischemia/reperfusion between trained and untrained individuals, using near infrared spectroscopy (NIRS) combined with a vascular occlusion test (VOT) technique (NIRS?￠????VOT). Sixteen untrained (26.3???????±????5.1????year) and seventeen trained (29.4???????±????4.9????year) healthy young adult men were submitted to a VOT (2????min baseline, 5????min occlusion, and 8????min reperfusion). Oxygen utilization was estimated from the area under the curve of the NIRS?￠????derived deoxyhemoglobin [HHb] signal during occlusion (AUCocc). Muscle reperfusion was derived from the area above the curve (AACrep) of the [HHb] signal after cuff release. The AUCocc of the untrained participants (21010???????±????9553????%???????·????s) was significantly larger than the AUCocc of their trained counterparts (12320???????±????3283????%???????·????s); P ????=????0.001). The AACrep of the untrained participants (5928???????±????3769????%???????·????s) was significantly larger than the AACrep of the trained participants (3745???????±????1900 %???????·????s; P ????=????0.042). There was a significant correlation between AUCocc and AACrep ( r ????=????0.840; P ????=????0.001). NIRS assessment of oxidative metabolism showed that trained individuals are more efficient in shifting between oxidative and anaerobic metabolism in response to ischemia and reperfusion.
机译：耐力训练与在缺血/再灌注过程中调节氧化代谢的骨骼肌适应有关。这项研究的目的是使用近红外光谱法（NIRS）结合血管阻塞试验（VOT）技术（NIRS）来无创地评估受过训练和未经训练的个体在缺血/再灌注过程中体内氧化代谢活性的差异。 ？￠ ???? VOT）。 16位未经训练的健康年轻人（26.3岁，±5.1年）和17位经过训练的（29.4岁，±4.9年）健康的年轻成年人男性接受了VOT（基线至少2分钟，阻塞5分钟和再灌注8分钟）。从在闭塞期间（AUCocc）源自NIRSΔβ-脱氧血红蛋白[HHb]信号的曲线下的面积估计氧气利用率。肌肉再灌注来自袖带释放后[HHb]信号曲线（AACrep）上方的区域。未经培训的参与者的AUCocc（21010 ????±±9553？%% ??????·??? s）显着大于其受过培训的同行者的AUCocc （12320 ???????±???? 3283 ????％???????··？s）; P≤0.001＝ 0.001）。未经训练的参与者的AACrep（5928 ???????±???? 3769 ????％?????????? s）显着大于训练有素的参与者的AACrep （3745 ??????±???? 1900％???????·？s; P ???? = ???? 0.042）。 AUCocc和AACrep之间有显着的相关性（r≥0.4＝ 0.840;P≥0.001）。 NIRS对氧化代谢的评估表明，受过训练的个体对缺血和再灌注的反应在氧化代谢和厌氧代谢之间转换的效率更高。

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