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首页> 外文期刊>Physiological Reports >Skeletal muscle adiponectin induction depends on diet, muscle type/activity, and exercise modality in C57BL/6 mice
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Skeletal muscle adiponectin induction depends on diet, muscle type/activity, and exercise modality in C57BL/6 mice

机译：骨骼肌脂联素的诱导取决于C57BL / 6小鼠的饮食，肌肉类型/活动和运动方式

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Changes in skeletal muscle adiponectin induction have been described in obesity and exercise. However, whether changes are consistent across muscle types and with different exercise modalities, remain unclear. This study compared the effects of diet and two isocaloric training programs on adiponectin induction and its regulators in three muscles: quadriceps (exercising/glycolytic‐oxidative), gastrocnemius (exercising/glycolytic), and masseter (nonexercising/glycolytic). Ten‐week‐old male C57BL/6 mice were fed a high‐fat diet (HFD) (45% fat) or standard CHOW diet (12% fat) ad?libitum and underwent one of two training regimes: (1) constant‐moderate training (END), or (2) high intensity interval training (HIIT) for 10?weeks (3?×?40?min sessions/week). Chow and HFD‐fed untrained mice were used as control. Compared with Chow, HFD induced an increase in protein levels of low‐molecular weight (LMW) adiponectin in gastrocnemius and masseter (~2‐fold; P ??0.05), and a decrease of high‐molecular weight adiponectin (HMW‐most bioactive form) in quadriceps (~0.5‐fold; P ??0.05). Only END prevented these changes ( P ??0.05). HFD induced a decrease of adiponectin receptor 1 (AdipoR1) protein in exercising muscles of untrained mice (~0.5‐0.8‐fold; P ??0.05); notably, END also decreased AdipoR1 protein levels in lean and HFD mice. This type of training also normalized HFD‐driven mRNA changes found in some adiponectin downstream factors (sirtuin 1, Pgc‐1a, and Ucp2) in the three muscles tested. Our results indicate that diet, muscle type/activity, and exercise modality influences muscle adiponectin profile, and some of its mediators. These parameters should be taken into consideration when investigating this endocrine response of the skeletal muscle, particularly in the context of obesity and metabolic disorders.
机译：肥胖和运动中已经描述了骨骼肌脂联素诱导的变化。但是，对于不同的肌肉类型和不同的运动方式，变化是否一致，仍不清楚。这项研究比较了饮食和两个等热量的训练计划对脂联素诱导及其在三块肌肉中的调节剂的影响：四头肌（锻炼/糖酵解-氧化），腓肠肌（锻炼/糖酵解）和咬肌（非锻炼/糖酵解）。十周龄的雄性C57BL / 6小鼠随意喂养高脂饮食（HFD）（脂肪45％）或标准CHOW饮食（脂肪12％），并接受以下两种训练方式之一：（1）恒定训练中等训练（END），或（2）高强度间歇训练（HIIT），持续10周（3××40分钟/周）。将Chow和HFD喂养的未经训练的小鼠用作对照。与Chow相比，HFD导致腓肠肌和咬肌中低分子量脂联素的蛋白质水平增加（〜2倍;P≤0.05），而高分子量脂联素（HMW股四头肌（〜0.5倍; P 0.05）。只有END阻止了这些变化（P <0.05）。 HFD诱导未训练小鼠的肌肉中脂联素受体1（AdipoR1）蛋白的减少（〜0.5-0.8-倍; P 0.05）;值得注意的是，END还降低了瘦小鼠和HFD小鼠的AdipoR1蛋白水平。这种训练还可以使测试的三块肌肉中某些脂联素下游因子（sirtuin 1，Pgc-1a和Ucp2）中的HFD驱动的mRNA变化正常化。我们的结果表明饮食，肌肉类型/活动和锻炼方式会影响肌肉脂联素谱及其某些介体。在研究骨骼肌的这种内分泌反应时，尤其是在肥胖和代谢异常的情况下，应考虑这些参数。

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