Wanted: A New Model for Glucocorticoid Receptor Transactivation and Transrepression

Caitlin Sedwick

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Wanted: A New Model for Glucocorticoid Receptor Transactivation and Transrepression

机译：想要：糖皮质激素受体反式激活和反抑制的新模型

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Glucocorticoid receptor (GR) is a transcription factor that is almost ubiquitous in vertebrate cells. As one of the cellular receptors for steroid hormones of the glucocorticoid (GC) family, which are well known for their anti-inflammatory properties in clinical applications, the regulation of GR activity has been the focus of intense study.

机译：糖皮质激素受体（GR）是一种在脊椎动物细胞中几乎普遍存在的转录因子。作为糖皮质激素（GC）家族类固醇激素的细胞受体之一，其在临床应用中具有抗炎特性，众所周知，GR活性的调节一直是研究的重点。

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《PLoS Biology》 |2014年第3期|共2页
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Caitlin Sedwick;
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中图分类分子生物学;
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1. PPARα blocks glucocorticoid receptor α-mediated transactivation but cooperates with the activated glucocorticoid receptor α for transrepression on NF-κB [J] . Nadia Bougarne, Rejane Paumelle, Sandrine Caron, Proceedings of the National Academy of Sciences of the United States of America . 2009,第18期

机译：PPARα阻断糖皮质激素受体α介导的反式激活，但与活化的糖皮质激素受体α协同作用以抑制NF-κB
2. JTP-117968, a novel selective glucocorticoid receptor modulator, exhibits improved transrepression/transactivation dissociation [J] . Kurimoto Takafumi, Tamai Isao, Miyai Atsuko, European Journal of Pharmacology: An International Journal . 2017,第期

机译：JTP-117968，一种新型选择性糖皮质激素受体调节剂，表现出改善的转型或反式激活解离
3. Comparative analysis of ginsenosides in human glucocorticoid receptor binding, transactivation, and transrepression [J] . Catherine Hu, Aik Jiang Lau, RuiQi Wang, European Journal of Pharmacology: An International Journal . 2017,第期

机译：人糖皮质激素受体结合，转移和转膜糖苷苷的比较分析
4. A New Transcript Splice Variant of the Human Glucocorticoid Receptor: Identification and Tissue Distribution of hGR△313-338, an Alternative Exon 2 Transactivation Domain Isoform [C] . JONATHAN D. TURNER, ANDREA B. SCHOTE, MARC KEIPES, Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：人糖皮质激素受体的一个新的转录剪接变体：hGR△313-338，另一外显子2反式激活域同工型的鉴定和组织分布。
5. Transcriptional regulation of the human aryl hydrocarbon receptor: Identification of multiple transactivation sub-domains and role of coactivators in modulating transactivation potential. [D] . Kumar, Mohan Basavaraju. 2000

机译：人类芳烃受体的转录调控：多个反式激活子域的识别和共激活剂在调节反式激活潜力中的作用。
6. PPARα blocks glucocorticoid receptor α-mediated transactivation but cooperates with the activated glucocorticoid receptor α for transrepression on NF-κB [O] . Nadia Bougarne, Réjane Paumelle, Sandrine Caron, 2009

机译：PPARα阻断糖皮质激素受体α介导的反式激活但与活化的糖皮质激素受体α协同作用以抑制NF-κB
7. PPARα blocks glucocorticoid receptor α-mediated transactivation but cooperates with the activated glucocorticoid receptor α for transrepression on NF-κB [O] . Bougarne, Nadia, Paumelle, Réjane, Caron, Sandrine, 2009

机译：PPARα阻断糖皮质激素受体α介导的反式激活，但与活化的糖皮质激素受体α协同作用以抑制NF-κB

Wanted: A New Model for Glucocorticoid Receptor Transactivation and Transrepression

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