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首页> 外文期刊>PLoS Biology >Variable Combinations of Specific Ephrin Ligand/Eph Receptor Pairs Control Embryonic Tissue Separation
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Variable Combinations of Specific Ephrin Ligand/Eph Receptor Pairs Control Embryonic Tissue Separation

机译：特定的Ephrin配体/ Eph受体对的可变组合控制胚胎组织分离。

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摘要

Ephrins and Eph receptors are involved in the establishment of vertebrate tissue boundaries. The complexity of the system is puzzling, however in many instances, tissues express multiple ephrins and Ephs on both sides of the boundary, a situation that should in principle cause repulsion between cells within each tissue. Although co-expression of ephrins and Eph receptors is widespread in embryonic tissues, neurons, and cancer cells, it is still unresolved how the respective signals are integrated into a coherent output. We present a simple explanation for the confinement of repulsion to the tissue interface: Using the dorsal ectoderm–mesoderm boundary of the Xenopus embryo as a model, we identify selective functional interactions between ephrin–Eph pairs that are expressed in partial complementary patterns. The combined repulsive signals add up to be strongest across the boundary, where they reach sufficient intensity to trigger cell detachments. The process can be largely explained using a simple model based exclusively on relative ephrin and Eph concentrations and binding affinities. We generalize these findings for the ventral ectoderm–mesoderm boundary and the notochord boundary, both of which appear to function on the same principles. These results provide a paradigm for how developmental systems may integrate multiple cues to generate discrete local outcomes.
机译：Ephrins和Eph受体参与脊椎动物组织边界的建立。该系统的复杂性令人费解，但是在许多情况下，组织在边界的两侧都表达多种ephrin和Ephs，这种情况原则上应引起每个组织内细胞之间的排斥。尽管ephrins和Eph受体的共表达在胚胎组织，神经元和癌细胞中很普遍，但如何将各个信号整合到一个一致的输出中仍未解决。我们提供了排斥力仅限于组织界面的简单解释：使用非洲爪蟾胚胎的背外胚层-中胚层边界作为模型，我们鉴定了以部分互补模式表达的ephrin-Eph对之间的选择性功能相互作用。合并的排斥信号在边界处加起来最强，在边界处达到足以触发细胞脱离的强度。可以使用仅基于相对ephrin和Eph浓度以及结合亲和力的简单模型在很大程度上解释该过程。我们将这些发现归纳为腹侧外胚层-中胚层边界和脊索边界，它们似乎都以相同的原理起作用。这些结果为发展系统如何整合多个线索以产生离散的局部结果提供了范例。

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