...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>PLoS Computational Biology >Gene Expression Divergence is Coupled to Evolution of DNA Structure in Coding Regions
【24h】

Gene Expression Divergence is Coupled to Evolution of DNA Structure in Coding Regions

机译：基因表达差异与编码区域DNA结构的进化有关

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sequence changes in coding region and regulatory region of the gene itself (cis) determine most of gene expression divergence between closely related species. But gene expression divergence between yeast species is not correlated with evolution of primary nucleotide sequence. This indicates that other factors in cis direct gene expression divergence. Here, we studied the contribution of DNA three-dimensional structural evolution as cis to gene expression divergence. We found that the evolution of DNA structure in coding regions and gene expression divergence are correlated in yeast. Similar result was also observed between Drosophila species. DNA structure is associated with the binding of chromatin remodelers and histone modifiers to DNA sequences in coding regions, which influence RNA polymerase II occupancy that controls gene expression level. We also found that genes with similar DNA structures are involved in the same biological process and function. These results reveal the previously unappreciated roles of DNA structure as cis-effects in gene expression.
机译：基因本身的编码区和调节区的序列变化（顺式）决定了密切相关物种之间的大多数基因表达差异。但是酵母物种之间的基因表达差异与一级核苷酸序列的进化无关。这表明顺式直接基因表达差异的其他因素。在这里，我们研究了DNA三维结构进化作为顺式对基因表达差异的贡献。我们发现，在酵母中，DNA结构在编码区的进化与基因表达的差异有关。果蝇物种之间也观察到类似的结果。 DNA结构与染色质重塑剂和组蛋白修饰剂与编码区DNA序列的结合有关，这会影响控制基因表达水平的RNA聚合酶II的占有率。我们还发现具有相似DNA结构的基因参与相同的生物学过程和功能。这些结果揭示了DNA结构作为基因表达中的顺式作用的先前未被认识的作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号