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Multifactorial Regulation of a Hox Target Gene

机译：Hox靶基因的多因素调控

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Hox proteins play fundamental roles in controlling morphogenetic diversity along the anterior–posterior body axis of animals by regulating distinct sets of target genes. Within their rather broad expression domains, individual Hox proteins control cell diversification and pattern formation and consequently target gene expression in a highly localized manner, sometimes even only in a single cell. To achieve this high-regulatory specificity, it has been postulated that Hox proteins co-operate with other transcription factors to activate or repress their target genes in a highly context-specific manner in vivo. However, only a few of these factors have been identified. Here, we analyze the regulation of the cell death gene reaper (rpr) by the Hox protein Deformed (Dfd) and suggest that local activation of rpr expression in the anterior part of the maxillary segment is achieved through a combinatorial interaction of Dfd with at least eight functionally diverse transcriptional regulators on a minimal enhancer. It follows that context-dependent combinations of Hox proteins and other transcription factors on small, modular Hox response elements (HREs) could be responsible for the proper spatio-temporal expression of Hox targets. Thus, a large number of transcription factors are likely to be directly involved in Hox target gene regulation in vivo.
机译：Hox蛋白通过调节目标基因的不同集合，在控制动物前后轴的形态发生多样性中起着基本作用。在其相当广泛的表达域内，单个Hox蛋白控制细胞的多样化和模式形成，因此以高度局部化的方式靶向基因表达，有时甚至仅在单个细胞中。为了达到这种高度调节的特异性，已经假定Hox蛋白与其他转录因子协同作用，以在体内高度背景特异性的方式激活或抑制其靶基因。但是，这些因素中只有少数几个被确定。在这里，我们分析了Hox蛋白变形（Dfd）对细胞死亡基因收割者（rpr）的调节，并建议通过Dfd与至少至少一部分的组合相互作用实现rpr表达在上颌节前部的局部活化。最小增强子上的八个功能多样的转录调节子。因此，Hox蛋白和其他转录因子在小型模块化Hox反应元件（HRE）上的上下文相关组合可能是Hox靶标正确时空表达的原因。因此，大量的转录因子可能直接参与体内Hox靶基因的调控。

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