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首页> 外文期刊>PLoS Genetics >The Bantam microRNA Is Associated with Drosophila Fragile X Mental Retardation Protein and Regulates the Fate of Germline Stem Cells
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The Bantam microRNA Is Associated with Drosophila Fragile X Mental Retardation Protein and Regulates the Fate of Germline Stem Cells

机译：矮脚鸡microRNA与果蝇脆弱X智力落后蛋白相关联，并调节生殖细胞的命运。

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Fragile X syndrome, a common form of inherited mental retardation, is caused by the loss of fragile X mental retardation protein (FMRP). We have previously demonstrated that dFmr1, the Drosophila ortholog of the fragile X mental retardation 1 gene, plays a role in the proper maintenance of germline stem cells in Drosophila ovary; however, the molecular mechanism behind this remains elusive. In this study, we used an immunoprecipitation assay to reveal that specific microRNAs (miRNAs), particularly the bantam miRNA (bantam), are physically associated with dFmrp in ovary. We show that, like dFmr1, bantam is not only required for repressing primordial germ cell differentiation, it also functions as an extrinsic factor for germline stem cell maintenance. Furthermore, we find that bantam genetically interacts with dFmr1 to regulate the fate of germline stem cells. Collectively, our results support the notion that the FMRP-mediated translation pathway functions through specific miRNAs to control stem cell regulation.
机译：脆性X综合征是遗传性智力低下的一种常见形式，是由脆性X智力低下蛋白（FMRP）的丧失引起的。我们先前已经证明了dFmr1，脆弱的X智力低下1基因的果蝇直系同源物，在果蝇卵巢中生殖系干细胞的正确维护中发挥着作用。然而，其背后的分子机制仍然难以捉摸。在这项研究中，我们使用免疫沉淀测定法揭示了特定的microRNA（miRNA），尤其是矮脚鸡miRNA（bantam），与卵巢中的dFmrp物理相关。我们表明，与dFmr1一样，矮脚鸡不仅是抑制原始生殖细胞分化所必需的，而且还起种系干细胞维持的外在因素的作用。此外，我们发现矮脚鸡与dFmr1遗传相互作用，调节种系干细胞的命运。总的来说，我们的研究结果支持以下观点：FMRP介导的翻译途径通过特定的miRNA来控制干细胞调节。

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