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首页> 外文期刊>PLoS Genetics >Genetic Determinants of Height Growth Assessed Longitudinally from Infancy to Adulthood in the Northern Finland Birth Cohort 1966
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Genetic Determinants of Height Growth Assessed Longitudinally from Infancy to Adulthood in the Northern Finland Birth Cohort 1966

机译：1966年在芬兰北部出生队列中从婴儿期到成年期对身高增长的遗传决定因素进行了纵向评估

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Recent genome-wide association (GWA) studies have identified dozens of common variants associated with adult height. However, it is unknown how these variants influence height growth during childhood. We derived peak height velocity in infancy (PHV1) and puberty (PHV2) and timing of pubertal height growth spurt from parametric growth curves fitted to longitudinal height growth data to test their association with known height variants. The study consisted of N?=?3,538 singletons from the prospective Northern Finland Birth Cohort 1966 with genotype data and frequent height measurements (on average 20 measurements per person) from 0–20 years. Twenty-six of the 48 variants tested associated with adult height (pHHIP, DLEU7, UQCC, SF3B4/SV2A, LCORL, and HIST1H1D associated with PHV1 and five SNPs in or near SOCS2, SF3B4/SV2A, C17orf67, CABLES1, and DOT1L with PHV2 (pSOCS2 (p?=?0.0030) and for the SNP in HHIP (p?=?0.045). We did not have similar prior evidence for the association between height variants and timing of pubertal height growth spurt as we had for PHVs, and none of the associations were statistically significant after correction for multiple testing. The fact that in this sample, less than half of the variants associated with adult height had a measurable effect on PHV1 or PHV2 is likely to reflect limited power to detect these associations in this dataset. Our study is the first genetic association analysis on longitudinal height growth in a prospective cohort from birth to adulthood and gives grounding for future research on the genetic regulation of human height during different periods of growth.
机译：最近的全基因组关联（GWA）研究已经确定了数十种与成年身高相关的常见变异。但是，尚不清楚这些变体如何影响儿童时期的身高增长。我们从适合纵向身高生长数据的参数生长曲线中得出婴儿期（PHV1）和青春期（PHV2）的峰值身高速度以及青春期身高突增的时间，以测试其与已知身高变异的关联。该研究包括来自预期的1966年芬兰北部出生队列的N？=？3,538个单例，其中包括基因型数据和0至20年内频繁进行的身高测量（平均每人20次测量）。测试的48个变体中有26个与成年身高相关（pHHIP，DLEU7，UQCC，SF3B4 / SV2A，LCORL和HIST1H1D与PHV1相关，以及SOCS2，SF3B4 / SV2A，C17orf67，CABLES1和DOT1L中或附近的五个SNP （pSOCS2（p？=？0.0030）和HHIP中的SNP（p？=？0.045）。与PHV相比，我们没有类似的先前证据表明身高变异与青春期身高突增时间之间的关联。经过多次测试校正后，这些关联均无统计学意义。在该样本中，与成年身高相关的变体中只有不到一半对PHV1或PHV2有可测量的影响，这一事实很可能反映了在这种情况下检测这些关联的能力有限我们的研究是对从出生到成年的前瞻性队列中纵向身高增长的首次遗传关联分析，为未来研究不同身高发育时期人类身高的遗传调控奠定了基础。

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