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Do We Need to Put Society First? The Potential for Tragedy in Antimicrobial Resistance

机译:我们需要把社会放在首位吗?抗菌素耐药性悲剧的可能性

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The use of antimicrobials has caused a proliferation of resistant pathogens (Figure 1), and most worryingly, some bacterial strains are resistant to multiple classes of drugs [1,2]. Policies are now being implemented to reduce antimicrobial use, with some encouraging successes [3,4]. However, here we argue that current policies may only partly solve the problem. In particular, they do not address the conundrum at the heart of antimicrobial resistance: the solution may ultimately require us to put society before the individual. That is, halting the rise of resistance may only be achievable if some patients go untreated. We defend this uncomfortable conclusion using the logic of the well-known social dilemma “the tragedy of the commons” [5]. More data on the societal costs of resistance are required to evaluate the potential for a tragedy of antimicrobial resistance and the moral dilemma that it would present.
机译:抗菌药物的使用已引起耐药病原体的扩散(图1),最令人担忧的是,某些细菌菌株对多种药物具有耐药性[1,2]。现在正在实施减少抗菌药物使用的政策,并取得了一些令人鼓舞的成功[3,4]。但是,在这里,我们认为当前的政策可能只能部分解决问题。特别是,它们并未解决抗药性核心问题:解决方案最终可能要求我们将社会置于个人之上。也就是说,只有在某些患者不接受治疗的情况下,才能阻止耐药性的上升。我们使用众所周知的社会困境“公地悲剧” [5]的逻辑来捍卫这一令人不安的结论。需要更多关于耐药性社会成本的数据,以评估可能发生的耐药性悲剧及其可能带来的道德困境。

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