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首页> 外文期刊>PLOS Neglected Tropical Diseases >Comparison of Schistosoma mansoni Soluble Cercarial Antigens and Soluble Egg Antigens for Serodiagnosing Schistosome Infections
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Comparison of Schistosoma mansoni Soluble Cercarial Antigens and Soluble Egg Antigens for Serodiagnosing Schistosome Infections

机译：曼氏血吸虫可溶性宫颈抗原和卵卵抗原在血清学诊断血吸虫感染中的比较

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摘要

A Schistosoma mansoni cercarial antigen preparation (cercarial transformation fluid – SmCTF) was evaluated for detection of anti-schistosome antibodies in human sera in 4 collaborating laboratories. The performance of SmCTF was compared with that of S. mansoni egg antigens (SmSEA) in an indirect enzyme-immunoassay (ELISA) antigen assay, the latter being used routinely in 3 of the 4 participating laboratories to diagnose S. mansoni and S. haematobium infections. In the fourth laboratory the performance of SmCTF was compared with that of S. japonicum egg antigens (SjSEA) in ELISA for detection of anti-S. japonicum antibodies. In all 4 laboratories the results given by SmCTF in ELISA were very similar to those given by the antigen preparation routinely used in the respective laboratory to detect anti-schistosome antibodies in human infection sera. In so far as the ELISA results from SmCTF are thus so little different from those given by schistosome egg antigens and also cheaper to produce, the former is a potentially useful new diagnostic aid for schistosomiasis.
机译：在四个合作实验室中，对曼氏血吸虫脑抗原制剂（脑转化液– SmCTF）进行了检测，以检测人血清中的抗血吸虫抗体。在间接酶免疫测定（ELISA）抗原测定中，将SmCTF与曼氏葡萄球菌卵抗原（SmSEA）的性能进行了比较，后者在4个参与实验室中的3个实验室中常规用于诊断曼氏葡萄球菌和血链球菌。感染。在第四个实验室中，在检测抗S的ELISA中将SmCTF与日本血吸虫卵抗原（SjSEA）的性能进行了比较。 ap抗体。在所有4个实验室中，SmCTF在ELISA中给出的结果与在各自实验室中常规用于检测人感染血清中抗血吸虫抗体的抗原制剂所给出的结果非常相似。由于SmCTF的ELISA结果与血吸虫卵抗原产生的差异不大，而且生产成本较低，前者是血吸虫病的潜在有用的新诊断手段。

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