Bothrops jararaca Venom Metalloproteinases Are Essential for Coagulopathy and Increase Plasma Tissue Factor Levels during Envenomation

Karine M. Yamashita; André F. Alves; Katia C. Barbaro; Marcelo L. Santoro

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Bothrops jararaca Venom Metalloproteinases Are Essential for Coagulopathy and Increase Plasma Tissue Factor Levels during Envenomation

机译：Bothrops jararaca毒液金属蛋白酶对于凝固性疾病至关重要，并在毒化过程中增加血浆组织因子水平

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Background /AimsBleeding tendency, coagulopathy and platelet disorders are recurrent manifestations in snakebites occurring worldwide. We reasoned that by damaging tissues and/or activating cells at the site of the bite and systemically, snake venom toxins might release or decrypt tissue factor (TF), resulting in activation of blood coagulation and aggravation of the bleeding tendency. Thus, we addressed (a) whether TF and protein disulfide isomerase (PDI), an oxireductase involved in TF encryption/decryption, were altered in experimental snake envenomation; (b) the involvement and significance of snake venom metalloproteinases (SVMP) and serine proteinases (SVSP) to hemostatic disturbances.

机译：背景/目的出血趋势，凝血病和血小板异常是世界各地发生的蛇咬伤的复发表现。我们认为，蛇毒毒素可通过破坏咬合部位的组织和/或激活细胞，并全身性地释放或解密组织因子（TF），从而导致血液凝结的活化和出血倾向的加剧。因此，我们研究了（a）在实验蛇毒化中，TF和蛋白质二硫键异构酶（PDI）是一种与TF加密/解密有关的氧化还原酶是否被改变; （b）蛇毒金属蛋白酶（SVMP）和丝氨酸蛋白酶（SVSP）对止血功能的影响及意义。

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《PLOS Neglected Tropical Diseases》 |2014年第5期|共12页
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Karine M. Yamashita; André F. Alves; Katia C. Barbaro; Marcelo L. Santoro;
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1. Neutralization of a snake venom hemorrhagic metalloproteinase prevents coagulopathy after subcutaneous injection of Bothrops jararaca venom in rats [J] . Anai K, Sugiki M, Yoshida E, Toxicon: An International Journal Devoted to the Exchange of Knowledge on the Poisons Derived from Animals, Plants and Microorganisms . 2002,第1期

机译：蛇毒出血性金属蛋白酶的中和可防止大鼠皮下注射Bothrops jararaca毒液后的凝血病
2. Elevated plasma levels of hepatocyte growth factor in rats experimentally envenomated with Bothrops jararaca venom: Role of snake venom metalloproteases [J] . Prezoto B. C., Kato E. E., Goncalves L. R. C., Toxicon: An International Journal Devoted to the Exchange of Knowledge on the Poisons Derived from Animals, Plants and Microorganisms . 2019,第期

机译：用βjararaca毒液实验向大鼠肝细胞生长因子的肝细胞生长因子的升高水平：蛇毒液金属蛋白酶的作用
3. Contribution of mast cells and snake venom metalloproteinases to the hyperalgesia induced by Bothrops jararaca venom in rats [J] . Bonavita AG, da Costa AS, Pires AL, Toxicon: An International Journal Devoted to the Exchange of Knowledge on the Poisons Derived from Animals, Plants and Microorganisms . 2006,第8期

机译：肥大细胞和蛇毒金属蛋白酶对百日草蛇毒诱导的痛觉过敏的作用
4. INCREASED SERUM TNF-ALPHA AND MATRIX METALLOPROTEINASE-2 ARE ASSOCIATED WITH GRIP STRENGTH DECLINES AND TISSUE DEGENERATION IN A RAT MODEL OF OVERUSE [C] . Helen G.L. Gao, Paul W Fisher, Christine K Wade, Human Factors and Ergonomics Society annual meeting . 2012

机译：在过度使用的大鼠模型中，血清TNF-α和基质金属蛋白酶2的增加与握力下降和组织退化有关
5. VENOM COAGGLUTININ (VCA). THE PLATELET AGGREGATING PRINCIPLE OF BOTHROPS VENOMS: VON WILLEBRAND FACTOR-DEPENDENT PLATELET AGGREGATION. [D] . READ, MARJORIE SHEARIN. 1983

机译：蛇毒凝集素（VCA）。蛇毒的血小板聚集原理：冯·威勒伯兰德依赖血小板的聚集。
6. Bothrops jararaca Venom Metalloproteinases Are Essential for Coagulopathy and Increase Plasma Tissue Factor Levels during Envenomation [O] . Karine M. Yamashita, André F. Alves, Katia C. Barbaro, 2014

机译：Bothrops jararaca毒液金属蛋白酶对于凝血功能至关重要并且在毒化过程中会增加血浆组织因子水平
7. Bothrops jararaca venom metalloproteinases are essential for coagulopathy and increase plasma tissue factor levels during envenomation. [O] . Karine M Yamashita, André F Alves, Katia C Barbaro, 2014

机译：Bothrops jararaca毒液金属蛋白酶对于凝血病是必需的，并且在通气期间增加血浆组织因子水平。

Bothrops jararaca Venom Metalloproteinases Are Essential for Coagulopathy and Increase Plasma Tissue Factor Levels during Envenomation

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