Evaluation of Antiviral Efficacy of Ribavirin, Arbidol, and T-705 (Favipiravir) in a Mouse Model for Crimean-Congo Hemorrhagic Fever

Lisa Oestereich; Toni Rieger; Melanie Neumann; Christian Bernreuther; Maria Lehmann; Susanne Krasemann; Stephanie Wurr; Petra Emmerich; Xavier de Lamballerie; Stephan ?lschl?ger; Stephan Günther

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Evaluation of Antiviral Efficacy of Ribavirin, Arbidol, and T-705 (Favipiravir) in a Mouse Model for Crimean-Congo Hemorrhagic Fever

机译：利巴韦林，Arbidol和T-705（Favipiravir）在克里米亚-刚果出血热的小鼠模型中的抗病毒效力评估

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Background Mice lacking the type I interferon receptor (IFNAR?/? mice) reproduce relevant aspects of Crimean-Congo hemorrhagic fever (CCHF) in humans, including liver damage. We aimed at characterizing the liver pathology in CCHF virus-infected IFNAR?/? mice by immunohistochemistry and employed the model to evaluate the antiviral efficacy of ribavirin, arbidol, and T-705 against CCHF virus.

机译：背景技术缺乏I型干扰素受体的小鼠（IFNARα/β小鼠）会在人类体内复制克里米亚-刚果出血热（CCHF）的相关方面，包括肝脏损害。我们旨在表征CCHF病毒感染的IFNARα/β的肝脏病理。小鼠通过免疫组织化学实验，并采用该模型评估利巴韦林，arbidol和T-705对CCHF病毒的抗病毒效力。

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《PLOS Neglected Tropical Diseases》 |2014年第5期|共15页
作者
Lisa Oestereich; Toni Rieger; Melanie Neumann; Christian Bernreuther; Maria Lehmann; Susanne Krasemann; Stephanie Wurr; Petra Emmerich; Xavier de Lamballerie; Stephan ?lschl?ger; Stephan Günther;
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1. Favipiravir (T-705) but not ribavirin is effective against two distinct strains of Crimean-Congo hemorrhagic fever virus in mice [J] . Hawman David W., Haddock Elaine, Meade-White Kimberly, Antiviral Research . 2018,第期

机译：Favipiravir（T-705）但不是利巴韦林对小鼠中的两个不同的克里米尔 - 刚果出血热病毒有效
2. Evaluation of the efficacy of ribavirin therapy on survival of Crimean-Congo hemorrhagic fever patients: a case-control study. [J] . Izadi S, Salehi M Japanese journal of infectious diseases . 2009,第1期

机译：利巴韦林疗法对克里米亚-刚果出血热患者生存的疗效评估：一项病例对照研究。
3. Efficacy of Favipiravir Alone and in Combination With Ribavirin in a Lethal, Immunocompetent Mouse Model of Lassa Fever [J] . Oestereich Lisa, Rieger Toni, Luedtke Anja, The Journal of Infectious Diseases . 2016,第6期

机译：单独使用Favipiravir并与利巴韦林联用在致死性免疫适应性拉沙热小鼠模型中的功效
4. Crimean-Congo Hemorrhagic Fever in Turkey (2002-2008) [C] . Etem AKBAS NATO Advanced Study Institute on Preparing Regional Leaders with Knowledge, Training and Instruments for Information Sharing Decision-making Against Biological Threats and Pandemics . 2010

机译：土耳其的克里米亚 - 刚果出血热（2002-2008）
5. Identification and characterization of the protease activity of the L protein of Crimean-Congo Hemorrhagic fever virus [D] . Frias-Staheli, Natalia 2008

机译：克里米亚-刚果出血热病毒L蛋白蛋白酶活性的鉴定和表征
6. Evaluation of Antiviral Efficacy of Ribavirin Arbidol and T-705 (Favipiravir) in a Mouse Model for Crimean-Congo Hemorrhagic Fever [O] . Lisa Oestereich, Toni Rieger, Melanie Neumann, 2014

机译：利巴韦林Arbidol和T-705（Favipiravir）在克里米亚-刚果出血热小鼠模型中的抗病毒效力评估
7. Evaluation of antiviral efficacy of ribavirin, arbidol, and T-705 (favipiravir) in a mouse model for Crimean-Congo hemorrhagic fever. [O] . Lisa Oestereich, Toni Rieger, Melanie Neumann, 2014

机译：评估利巴韦林，阿比朵尔和T-705（favipiravir）在克里米亚 - 刚果出血热小鼠模型中的抗病毒效力。
8. Simple Assay for Determining Antiviral Activity Against Crimean-Congo Hemorrhagic Fever Virus [R] . Paragas, J. , Whitehouse, C. A. , Endy, T. P. , 2004

机译：确定克里米亚 - 刚果出血热病毒抗病毒活性的简便方法

Evaluation of Antiviral Efficacy of Ribavirin, Arbidol, and T-705 (Favipiravir) in a Mouse Model for Crimean-Congo Hemorrhagic Fever

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