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首页> 外文期刊>PLOS Neglected Tropical Diseases >Protective Efficacy of a Plasmodium vivax Circumsporozoite Protein-Based Vaccine in Aotus nancymaae Is Associated with Antibodies to the Repeat Region
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Protective Efficacy of a Plasmodium vivax Circumsporozoite Protein-Based Vaccine in Aotus nancymaae Is Associated with Antibodies to the Repeat Region

机译：南天牛疟原虫间日疟原虫环子孢子蛋白疫苗的保护功效与重复区域抗体相关。

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We have previously reported that Vivax Malaria Protein 001 (VMP001), a vaccine candidate based on the circumsporozoite protein of Plasmodium vivax, is immunogenic in mice and rhesus monkeys in the presence of various adjuvants. In the present study, we evaluated the immunogenicity and efficacy of VMP001 formulated with a TLR9 agonist in a water-in-oil emulsion. Following immunization, the vaccine efficacy was assessed by challenging Aotus nancymaae monkeys with P. vivax sporozoites. Monkeys from both the low- and high-dose vaccine groups generated strong humoral immune responses to the vaccine (peak median titers of 291,622), and its subunits (peak median titers to the N-term, central repeat and C-term regions of 22,188; 66,120 and 179,947, respectively). 66.7% of vaccinated monkeys demonstrated sterile protection following challenge. Protection was associated with antibodies directed against the central repeat region. The protected monkeys had a median anti-repeat titer of 97,841 compared to 14,822 in the non-protected monkeys. This is the first report demonstrating P. vivax CSP vaccine-induced protection of Aotus monkeys challenged with P. vivax sporozoites.
机译：我们以前曾报道过，Vivax疟疾蛋白001（VMP001）是一种基于间日疟原虫环子孢子蛋白的候选疫苗，在多种佐剂存在下对小鼠和恒河猴具有免疫原性。在本研究中，我们评估了在油包水乳液中用TLR9激动剂配制的VMP001的免疫原性和功效。免疫后，通过用间日疟原虫子孢子攻击Aotus nancymaae猴子评估疫苗效力。来自低剂量和高剂量疫苗组的猴子均对该疫苗及其亚基产生强烈的体液免疫反应（峰值中值滴度为291,622），其亚基（N末端，中央重复和C末端区域的峰值中值滴度为22,188） ;分别为66,120和179,947）。攻击后66.7％的接种猴子表现出无菌保护作用。保护与针对中央重复区域的抗体相关。受保护的猴子的平均抗重复滴度为97,841，相比之下，未受保护的猴子的抗重复滴度为14,822。这是第一份证明间日疟原虫CSP疫苗诱导的对间日疟原虫子孢子攻击的Aotus猴子的保护的报告。

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