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首页> 外文期刊>PLOS Neglected Tropical Diseases >Whole Genome Amplification and Reduced-Representation Genome Sequencing of Schistosoma japonicum Miracidia
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Whole Genome Amplification and Reduced-Representation Genome Sequencing of Schistosoma japonicum Miracidia

机译：日本血吸虫Miracidia的全基因组扩增和代表性减少的基因组测序

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Background In areas where schistosomiasis control programs have been implemented, morbidity and prevalence have been greatly reduced. However, to sustain these reductions and move towards interruption of transmission, new tools for disease surveillance are needed. Genomic methods have the potential to help trace the sources of new infections, and allow us to monitor drug resistance. Large-scale genotyping efforts for schistosome species have been hindered by cost, limited numbers of established target loci, and the small amount of DNA obtained from miracidia, the life stage most readily acquired from humans. Here, we present a method using next generation sequencing to provide high-resolution genomic data from S. japonicum for population-based studies.
机译：背景技术在已实施血吸虫病控制计划的地区，发病率和患病率已大大降低。然而，为了维持这些减少并走向传播中断，需要新的疾病监测工具。基因组方法有潜力帮助追踪新感染的来源，并使我们能够监测耐药性。血吸虫病物种的大规模基因分型工作已受到成本，已建立的目标基因座数量有限以及从水acid症（人类最容易获得的生命阶段）中获得的少量DNA的阻碍。在这里，我们提出了一种使用下一代测序技术提供基于日本血吸虫的高分辨率基因组数据以进行基于人群的研究的方法。

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