HIV Treatment as Prevention: Systematic Comparison of Mathematical Models of the Potential Impact of Antiretroviral Therapy on HIV Incidence in South Africa

Jeffrey W. Eaton; Leigh F. Johnson; Joshua A. Salomon; Till B?rnighausen; Eran Bendavid; Anna Bershteyn; David E. Bloom; Valentina Cambiano; Christophe Fraser; Jan A. C. Hontelez; Salal Humair; Daniel J. Klein; Elisa F. Long; Andrew N. Phillips; Carel Pretorius; John Stover; Edward A. Wenger; Brian G. Williams; Timothy B. Hallett

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HIV Treatment as Prevention: Systematic Comparison of Mathematical Models of the Potential Impact of Antiretroviral Therapy on HIV Incidence in South Africa

机译：作为预防措施的艾滋病毒治疗：南非抗逆转录病毒疗法对艾滋病毒发病率潜在影响的数学模型的系统比较

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Background Many mathematical models have investigated the impact of expanding access to antiretroviral therapy (ART) on new HIV infections. Comparing results and conclusions across models is challenging because models have addressed slightly different questions and have reported different outcome metrics. This study compares the predictions of several mathematical models simulating the same ART intervention programmes to determine the extent to which models agree about the epidemiological impact of expanded ART.

机译：背景技术许多数学模型已经研究了扩大抗逆转录病毒疗法（ART）的使用对新的HIV感染的影响。比较模型之间的结果和结论是具有挑战性的，因为模型解决了略有不同的问题，并报告了不同的结果指标。这项研究比较了模拟相同ART干预计划的几种数学模型的预测，以确定模型对扩展ART的流行病学影响达成共识的程度。

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《PLoS Medicine》 |2012年第7期|共20页
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Jeffrey W. Eaton; Leigh F. Johnson; Joshua A. Salomon; Till B?rnighausen; Eran Bendavid; Anna Bershteyn; David E. Bloom; Valentina Cambiano; Christophe Fraser; Jan A. C. Hontelez; Salal Humair; Daniel J. Klein; Elisa F. Long; Andrew N. Phillips; Carel Pretorius; John Stover; Edward A. Wenger; Brian G. Williams; Timothy B. Hallett;
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1. Evaluation of the impact of immediate versus WHO recommendations-guided antiretroviral therapy initiation on HIV incidence: the ANRS 12249 TasP (Treatment as Prevention) trial in Hlabisa sub-district, KwaZulu-Natal, South Africa: study protocol for a cluster randomised controlled trial [J] . Collins C Iwuji, Joanna Orne-Gliemann, Frank Tanser, Trials . 2013,第1期

机译：评估即刻与世卫组织建议指导的抗逆转录病毒疗法的启动对HIV发病率的影响：南非夸祖鲁-纳塔尔省哈拉巴萨区的ANRS 12249 TasP（预防性治疗）试验：一项整群随机对照试验的研究方案
2. Renal dysfunction by baseline CD CD 4 cell count in a cohort of adults starting antiretroviral treatment regardless of CD CD 4 count in the HIV Prevention Trials Network 071 [ HPTN 071 HPTN 071 ; Population Effect of Antiretroviral Therapy to Reduce HIV Transmission (Pop ART ART )] study in South Africa [J] . Bock P, Nel K, Fatti G, HIV medicine . 2019,第6期

机译：基线CD CD 4细胞计数在成人队列中的肾功能障碍起始抗逆转录病毒治疗，无论CD CD 4计数如何在HIV预防试验网络071 [HPTN 071 HPTN 071; 抗逆转录病毒治疗对南非艾滋病毒传播（波普艺术）的人口效应
3. Assessment of epidemic projections using recent HIV survey data in South Africa: a validation analysis of ten mathematical models of HIV epidemiology in the antiretroviral therapy era [J] . Jeffrey W Eaton, Nicolas Baca?r, Anna Bershteyn, The Lancet Global Health . 2015,第10期

机译：使用南非最近的艾滋病毒调查数据评估流行病预测：抗逆转录病毒疗法时代的十种艾滋病毒流行病数学模型的验证分析
4. PREVENTION OF HIV-1 INFECTION WITH EARLY ANTIRETROVIRAL THERAPY: TREATMENT AS PREVENTION-TASP [C] . ISHWAR GILADA, T. GILADA International Seminar on Nuclear War and Planetary Emergencies . 2014

机译：预防早期抗逆转录病毒治疗的HIV-1感染：治疗预防 - TASP
5. Antiretroviral Treatment as Prevention in African HIV-1 Serodiscordant Couples: Understanding the Challenges and Opportunities. [D] . Mujugira, Andrew. 2016

机译：抗逆转录病毒治疗作为预防非洲HIV-1血清恶性夫妇的方法：了解挑战和机遇。
6. HIV Treatment as Prevention: Systematic Comparison of Mathematical Models of the Potential Impact of Antiretroviral Therapy on HIV Incidence in South Africa [O] . Jeffrey W. Eaton, Leigh F. Johnson, Joshua A. Salomon, 2012

机译：作为预防措施的艾滋病毒治疗：南非抗逆转录病毒疗法对艾滋病毒发病率潜在影响的数学模型的系统比较
7. HIV treatment as prevention: Systematic comparison of mathematical models of the potential impact of antiretroviral therapy on HIV incidence in South Africa [O] . Eaton J.W. (Jeffrey), Johnson L.F. (Leigh), Salomon J.A. (Joshua), 2012

机译：作为预防的艾滋病毒治疗：南非抗病毒治疗对艾滋病毒感染率潜在影响的数学模型的系统比较

HIV Treatment as Prevention: Systematic Comparison of Mathematical Models of the Potential Impact of Antiretroviral Therapy on HIV Incidence in South Africa

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