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首页> 外文期刊>PLoS Medicine >Reassessment of HIV-1 Acute Phase Infectivity: Accounting for Heterogeneity and Study Design with Simulated Cohorts
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Reassessment of HIV-1 Acute Phase Infectivity: Accounting for Heterogeneity and Study Design with Simulated Cohorts

机译：HIV-1急性期感染性的重新评估：异质性和模拟队列研究设计。

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Background The infectivity of the HIV-1 acute phase has been directly measured only once, from a retrospectively identified cohort of serodiscordant heterosexual couples in Rakai, Uganda. Analyses of this cohort underlie the widespread view that the acute phase is highly infectious, even more so than would be predicted from its elevated viral load, and that transmission occurring shortly after infection may therefore compromise interventions that rely on diagnosis and treatment, such as antiretroviral treatment as prevention (TasP). Here, we re-estimate the duration and relative infectivity of the acute phase, while accounting for several possible sources of bias in published estimates, including the retrospective cohort exclusion criteria and unmeasured heterogeneity in risk.
机译：背景从回顾性鉴定的乌干达拉凯的血清型异性恋夫妇队列中，仅直接测量了HIV-1急性期的传染性。对这一人群的分析奠定了普遍的观点，即急性期具有高度感染性，甚至比病毒载量升高所预测的要高得多，因此感染后不久发生的传播可能会损害依赖于诊断和治疗的干预措施，例如抗逆转录病毒预防治疗（TasP）。在这里，我们重新估算了急性期的持续时间和相对传染性，同时考虑了已发表估算中几种可能的偏差来源，包括回顾性队列排除标准和风险中未测得的异质性。

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