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首页> 外文期刊>PLOS Neglected Tropical Diseases >Integrated seroprevalence-based assessment of Wuchereria bancrofti and Onchocerca volvulus in two lymphatic filariasis evaluation units of Mali with the SD Bioline Onchocerciasis/LF IgG4 Rapid Test
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Integrated seroprevalence-based assessment of Wuchereria bancrofti and Onchocerca volvulus in two lymphatic filariasis evaluation units of Mali with the SD Bioline Onchocerciasis/LF IgG4 Rapid Test

机译:通过SD Bioline Onchocerciasis / LF IgG4快速测试,在马里的两个淋巴丝虫病评估单位中,基于血清阳性率综合评估Wuchereria bancrofti和Onchocerca volvulus

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Author summary After years of mass drug administration for lymphatic filariasis and onchocerciasis, many co-endemic countries need to demonstrate the interruption of transmission of these parasitic infections. This interruption of transmission is the key to stopping mass drug administration. One of the major challenges facing national programs is a reliable point of care diagnostic tool capable of detecting recent infection in children. To this end, the SD Bioline Onchocerciasis / LF IgG4 Rapid Test was used to evaluate the transmission interruption of lymphatic filariasis and onchocerciasis in previously endemic regions of Mali. This rapid diagnostic tool demonstrated good performance in 6 of districts in 2 'so-called' evaluation units. There was very good overlap of the serological results obtained by the rapid diagnostic test (RDT) and previous endemicity profile of the different study districts for the two infections. We would argue that this RDT could be a single integrated approach for assessing transmission in areas where lymphatic filariasis and onchocerciasis are/were co-endemic.
机译:作者总结经过多年的淋巴丝虫病和盘尾丝虫病大规模药物管理,许多共同流行国家都需要证明这些寄生虫感染的传播受到干扰。传播的这种中断是停止大规模药物管理的关键。国家计划面临的主要挑战之一是能够检测儿童近期感染的可靠的护理点诊断工具。为此,SD Bioline盘尾丝虫病/ LF IgG4快速测试用于评估马里先前流行地区的淋巴丝虫病和盘尾丝虫病的传播中断。这种快速诊断工具在2个“所谓”评估单位中的6个地区表现出良好的性能。通过快速诊断测试(RDT)获得的血清学结果与两种研究的不同研究区的先前流行特征之间存在很好的重叠。我们认为,该RDT可能是评估淋巴丝虫病和盘尾丝虫病并存/流行的地区的传播的单一综合方法。

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