Miltefosine and Antimonial Drug Susceptibility of Leishmania Viannia Species and Populations in Regions of High Transmission in Colombia

Olga Lucía Fernández; Yira Diaz-Toro; Clemencia Ovalle; Liliana Valderrama; Sandra Muvdi; Isabel Rodríguez; María Adelaida Gomez; Nancy Gore Saravia

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Miltefosine and Antimonial Drug Susceptibility of Leishmania Viannia Species and Populations in Regions of High Transmission in Colombia

机译：哥伦比亚高传播地区利什曼原虫Viannia物种和种群的Miltefosine和锑药物敏感性

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Background Pentavalent antimonials have been the first line treatment for dermal leishmaniasis in Colombia for over 30 years. Miltefosine is administered as second line treatment since 2005. The susceptibility of circulating populations of Leishmania to these drugs is unknown despite clinical evidence supporting the emergence of resistance.

机译：背景技术五价锑已成为哥伦比亚皮肤利什曼病的一线治疗已有30多年的历史了。自2005年以来，米线磷碱开始作为二线治疗药物使用。尽管有临床证据支持耐药性的出现，但利什曼原虫循环种群对这些药物的敏感性尚不清楚。

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《PLOS Neglected Tropical Diseases》 |2014年第5期|共11页
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Olga Lucía Fernández; Yira Diaz-Toro; Clemencia Ovalle; Liliana Valderrama; Sandra Muvdi; Isabel Rodríguez; María Adelaida Gomez; Nancy Gore Saravia;
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专利

1. Correction: Miltefosine and Antimonial Drug Susceptibility of Leishmania Viannia Species and Populations in Regions of High Transmission in Colombia [J] . The PLOS Neglected Tropical Diseases Staff PLOS Neglected Tropical Diseases . 2014,第6期

机译：矫正：在哥伦比亚高传播区域的Leishmania Viannia物种和群体的Miltefosine和锑药物易感性
2. Treatment failure and miltefosine susceptibility in dermal leishmaniasis caused by leishmania subgenus viannia species [J] . ObonagaR., FernándezO.L., ValderramaL., Antimicrobial agents and chemotherapy. . 2014,第1期

机译：利什曼原虫亚属物种引起的皮肤利什曼病的治疗失败和米洛西汀敏感性
3. GENETIC STRUCTURE OF LUTZOMYIA (NYSSOMYIA) INTERMEDIA POPULATIONS FROM TWO ECOLOGIC REGIONS IN BRAZIL WHERE TRANSMISSION OF LEISHMANIA (VIANNIA) BRAZILIENSIS REFLECTS DISTINCT ECO-EPIDEMIOLOGIC FEATURES [J] . DE SOUZA ROCHA LEONARDO, FALQUETO ALOISIO, DOS SANTOS CLAUDINEY BIRAL, American Journal of Tropical Medicine and Hygiene . 2007,第3期

机译：巴西利什曼原虫传播的两个生态区狼毒症（NYSSOMYIA）中间种群的遗传结构反映了不同的生态流行特征
4. Miltefosine incorporated hydrogel-doxorubicin conjugate as tumor responsive locoregional drug depot for combination chemotherapy [C] . Biji Balakrishnan, Nitin Joshi, Shahdeep Kaur, World biomaterials congress . 2016

机译：Miltefosine掺入水凝胶-阿霉素结合物作为组合化疗的肿瘤反应局部药物库
5. Kinetic and structural characterization of species-unique regions in Cryptosporidium hominis TS-DHFR towards novel species-specific drug design. [D] . Martucci, Walter Edward. 2009

机译：人型隐孢子虫TS-DHFR中物种独特区域对新型物种特异性药物设计的动力学和结构表征。
6. Correction: Miltefosine and Antimonial Drug Susceptibility of Leishmania Viannia Species and Populations in Regions of High Transmission in Colombia [O] . 2014

机译：校正：哥伦比亚高传播地区利什曼原虫Viannia物种和种群的Miltefosine和锑药物敏感性
7. Miltefosine and antimonial drug susceptibility of Leishmania Viannia species and populations in regions of high transmission in Colombia. [O] . Olga Lucía Fernández, Yira Diaz-Toro, Clemencia Ovalle, 2014

机译：哥伦比亚高传播地区利什曼原虫（Leishmania Viannia）物种和种群的米替福新和抗癫痫药物敏感性。
8. In vitro Susceptibility of Antimony-Resistant Leishmania to Alternative Drugs [R] . Berman, J. D. 1981

机译：抗锑利什曼原虫对替代药物的体外敏感性

Miltefosine and Antimonial Drug Susceptibility of Leishmania Viannia Species and Populations in Regions of High Transmission in Colombia

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