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首页> 外文期刊>PLOS Neglected Tropical Diseases >Japanese Encephalitis—A Pathological and Clinical Perspective
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Japanese Encephalitis—A Pathological and Clinical Perspective

机译：日本脑炎的病理学和临床研究

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Japanese encephalitis (JE) is the leading form of viral encephalitis in Asia. It is caused by the JE virus (JEV), which belongs to the family Flaviviridae. JEV is endemic to many parts of Asia, where periodic outbreaks take hundreds of lives. Despite the catastrophes it causes, JE has remained a tropical disease uncommon in the West. With rapid globalization and climatic shift, JEV has started to emerge in areas where the threat was previously unknown. Scientific evidence predicts that JEV will soon become a global pathogen and cause of worldwide pandemics. Although some research documents JEV pathogenesis and drug discovery, worldwide awareness of the need for extensive research to deal with JE is still lacking. This review focuses on the exigency of developing a worldwide effort to acknowledge the prime importance of performing an extensive study of this thus far neglected tropical viral disease. This review also outlines the pathogenesis, the scientific efforts channeled into develop a therapy, and the outlook for a possible future breakthrough addressing this killer disease.
机译：日本脑炎（JE）是亚洲病毒性脑炎的主要形式。它是由属于黄病毒科的JE病毒（JEV）引起的。 JEV是亚洲许多地方的地方病，那里的定期暴发导致数百人丧生。尽管造成了灾难，但JE仍然是西方罕见的热带病。随着全球化的迅速发展和气候变化，JEV已经开始在以前未知威胁的地区出现。科学证据预测，JEV将很快成为全球病原体和全球流行病的起因。尽管一些研究记录了JEV的发病机理和药物发现，但全世界仍缺乏对广泛研究以应对JE的需求的认识。这篇综述着重于开展一项全球努力的迫切性，以认识到对这一迄今被忽视的热带病毒病进行广泛研究的首要重要性。这篇综述还概述了发病机理，为开发一种疗法而进行的科学努力以及解决这一致命疾病的未来可能突破的前景。

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