Heme crystallization in a Chagas disease vector acts as a redox-protective mechanism to allow insect reproduction and parasite infection

Caroline M. Ferreira; Renata Stiebler; Francis M. Saraiva; Guilherme C. Lechuga; Ana Beatriz Walter-Nuno; Saulo C. Bourguignon; Marcelo S. Gonzalez; Patrícia Azambuja; Ana Caroline P. Gandara; Rubem F. S. Menna-Barreto; Gabriela O. Paiva-Silva; Marcia C. Paes; Marcus F. Oliveira

首页> 外文期刊>PLOS Neglected Tropical Diseases >Heme crystallization in a Chagas disease vector acts as a redox-protective mechanism to allow insect reproduction and parasite infection

【24h】

Heme crystallization in a Chagas disease vector acts as a redox-protective mechanism to allow insect reproduction and parasite infection

机译：恰加斯病病毒载体中的血红素结晶起氧化还原保护作用，可允许昆虫繁殖和寄生虫感染

获取原文

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Author summary Chagas disease is a fatal illness caused by Trypanosoma cruzi parasites, which are transmitted by blood sucking triatomine insect vectors. Although blood is a natural food source for these insects, its digestion releases toxic products, which poses a dietary challenge for both triatomine insects and trypanosomes. To overcome this, triatomines eliminate these toxic blood products by a unique process of heme crystallization into hemozoin that take place in their digestive tract. Here we describe that this detoxification process represents the major mechanism for redox balance control, and is necessary to allow triatomine insect reproduction, and Trypanosoma cruzi infection. Disruption of heme crystallization in triatomine insects thus represents a new venue for Chagas disease control, by targeting at the same time insect reproduction and parasite transmission.

机译：作者摘要恰加斯病是由克鲁氏锥虫寄生虫引起的致命疾病，锥虫是通过吸血三聚氰胺昆虫载体传播的。尽管血液是这些昆虫的天然食物来源，但血液的消化会释放出有毒的产品，这对三atom素昆虫和锥虫都构成了饮食挑战。为了克服这个问题，三氢嘧啶类化合物通过在其消化道中发生的血红素独特的血红素结晶过程，消除了这些有毒的血液产物。在这里，我们描述了此排毒过程代表了氧化还原平衡控制的主要机制，并且对于允许散发三聚氰胺的昆虫繁殖和克氏锥虫感染是必要的。因此，通过同时靶向昆虫繁殖和寄生虫传播，破坏了三硅藻类昆虫中血红素的结晶，为控制南美锥虫病提供了新的场所。

著录项

来源
《PLOS Neglected Tropical Diseases》 |2018年第7期|共20页
作者
Caroline M. Ferreira; Renata Stiebler; Francis M. Saraiva; Guilherme C. Lechuga; Ana Beatriz Walter-Nuno; Saulo C. Bourguignon; Marcelo S. Gonzalez; Patrícia Azambuja; Ana Caroline P. Gandara; Rubem F. S. Menna-Barreto; Gabriela O. Paiva-Silva; Marcia C. Paes; Marcus F. Oliveira;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种
中图分类传染病;
关键词
HemeBloodInsectsTrypanosoma cruziOxidation-reduction reactionsInsect vectorsCrystallizationInsect physiology;

机译：血红素血昆虫克鲁氏锥虫氧化还原反应昆虫载体结晶昆虫生理;

相似文献

外文文献
中文文献
专利

1. Studies in search of a suitable experimental insect model for xenodiagnosis of hosts with Chagas' disease: 4 - The reflection of parasite stock in the responsiveness of different vector species to chronic infection with different Trypanosoma cruzi stocks [J] . Alina Perlowagora-szumlewicz, Carlos Alberto Muller, Carlos José De Carvalho Moreira Revista de Saúde Pública . 1990,第3期

机译：为寻找恰加斯氏病宿主的异种诊断而寻找合适的实验昆虫模型的研究：4-寄生虫种群在不同媒介物种对克鲁氏锥虫种群的慢性感染反应中的反映
2. Studies in search of a suitable experimental insect model for xenodiagnosis of hosts with Chagas' disease: 3 - On the interaction of vector species and parasite strain in the reaction of bugs to infection by Trypanosoma cruzi [J] . Alina Perlowagora-szumlewicz, Carlos Alberto Muller, Carlos José De Carvalho Moreira Revista de Saúde Pública . 1988,第5期

机译：寻找适合查加斯氏病宿主的异种诊断的实验昆虫模型的研究：3-关于媒介物种和寄生虫菌株在臭虫对克氏锥虫感染的反应中的相互作用
3. Studies in search of a suitable experimental insect model for xenodiagnosis of hosts with Chagas' disease: 3 - On the interaction of vector species and parasite strain in the reaction of bugs to infection by Trypanosoma cruzi [J] . Alina Perlowagora-szumlewicz, Carlos Alberto Muller, Carlos José De Carvalho Moreira Revista de Saúde Pública . 1988,第5期

机译：寻找适合查加斯氏病宿主的异种诊断的实验昆虫模型的研究：3-关于媒介物种和寄生虫菌株在臭虫对克氏锥虫感染的反应中的相互作用
4. The Role of Proteomics in Deciphering the Intracellular Mechanism of Diuresis by the Insect Vector of Chagas' DiseaseRhodniusprolixus [C] . Noman Hassan, Rachit Batta, Paula Gioino, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：蛋白质组学对解毒虫的虫虫的植物细胞瘤的作用
5. Expression and Functional Sialome of Triatomines, Insect Vectors of Chagas Disease [D] . Mendes, Maria Tays. 2020

机译：三族瘤的表达和功能性Sialome，Chagas病的昆虫载体
6. Heme crystallization in a Chagas disease vector acts as a redox-protective mechanism to allow insect reproduction and parasite infection [O] . Caroline M. Ferreira, Renata Stiebler, Francis M. Saraiva, 2018

机译：恰加斯病病毒载体中的血红素结晶起氧化还原保护机制的作用允许昆虫繁殖和寄生虫感染
7. Studies in search of a suitable experimental insect model for xenodiagnosis of hosts with Chagas' disease: 4 - The reflection of parasite stock in the responsiveness of different vector species to chronic infection with different Trypanosoma cruzi stocks Estudos em busca de um inseto modelo para o xenodiagnóstico em hospedeiros com doença de Chagas: 4 - O reflexo da cepa do parasito na resposta de diferentes espécies vetoras à infecção crônica com diferentes isolados do Trypanosoma cruzi [O] . Alina Perlowagora-Szumlewicz, Carlos Alberto Muller, Carlos José de Carvalho Moreira 1990

机译：寻找合适的实验昆虫模型用于查格斯病的宿主异种病的研究：4 - 寄生虫种群对不同载体物种对不同克氏锥虫慢性感染的反应性的反映研究寻找用于异种诊断的模型昆虫在具有恰加斯病的宿主中：4 - 不同载体对不同克氏锥虫分离株慢性感染的反应中的寄生菌株反射

Heme crystallization in a Chagas disease vector acts as a redox-protective mechanism to allow insect reproduction and parasite infection

摘要

著录项

相似文献

相关主题

期刊订阅