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首页> 外文期刊>PLOS Neglected Tropical Diseases >Consequences of the Expanding Global Distribution of Aedes albopictus for Dengue Virus Transmission
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Consequences of the Expanding Global Distribution of Aedes albopictus for Dengue Virus Transmission

机译：白纹伊蚊传播登革热病毒的全球分布扩大的后果

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The dramatic global expansion of Aedes albopictus in the last three decades has increased public health concern because it is a potential vector of numerous arthropod-borne viruses (arboviruses), including the most prevalent arboviral pathogen of humans, dengue virus (DENV). Ae. aegypti is considered the primary DENV vector and has repeatedly been incriminated as a driving force in dengue's worldwide emergence. What remains unresolved is the extent to which Ae. albopictus contributes to DENV transmission and whether an improved understanding of its vector status would enhance dengue surveillance and prevention. To assess the relative public health importance of Ae. albopictus for dengue, we carried out two complementary analyses. We reviewed its role in past dengue epidemics and compared its DENV vector competence with that of Ae. aegypti. Observations from “natural experiments” indicate that, despite seemingly favorable conditions, places where Ae. albopictus predominates over Ae. aegypti have never experienced a typical explosive dengue epidemic with severe cases of the disease. Results from a meta-analysis of experimental laboratory studies reveal that although Ae. albopictus is overall more susceptible to DENV midgut infection, rates of virus dissemination from the midgut to other tissues are significantly lower in Ae. albopictus than in Ae. aegypti. For both indices of vector competence, a few generations of mosquito colonization appear to result in a relative increase of Ae. albopictus susceptibility, which may have been a confounding factor in the literature. Our results lead to the conclusion that Ae. albopictus plays a relatively minor role compared to Ae. aegypti in DENV transmission, at least in part due to differences in host preferences and reduced vector competence. Recent examples of rapid arboviral adaptation to alternative mosquito vectors, however, call for cautious extrapolation of our conclusion. Vector status is a dynamic process that in the future could change in epidemiologically important ways.
机译：在过去的三十年中，白纹伊蚊在全球范围内的急剧扩张引起了公众健康的关注，因为它是许多节肢动物传播的病毒（虫媒病毒）的潜在载体，其中包括人类最流行的虫媒病毒病原体登革热病毒（DENV）。 e埃及被认为是登革热的主要传播媒介，并被一再认为是登革热全球流行的驱动力。尚未解决的是Ae的程度。 albopictus有助于DENV的传播，以及对其媒介状况的更好了解是否会加强登革热的监测和预防。评估Ae相对公共卫生的重要性。对于登革热白纹病，我们进行了两项补充分析。我们回顾了其在过去登革热流行中的作用，并将其与AE的DENV载体能力进行了比较。埃及。来自“自然实验”的观察结果表明，尽管看似有利，但地方还是Ae。白纹杆菌占优势。埃及从来没有经历过严重的登革热流行和严重的疾病病例。对实验实验室研究进行荟萃分析的结果表明，尽管Ae。总体而言，白化病更容易感染DENV中肠，Ae中从中肠到其他组织的病毒传播速度明显降低。白比阿比。埃及。对于媒介能力的两个指标，几代蚊子定居似乎导致Ae的相对增加。白化病的易感性，可能是文献中令人困惑的因素。我们的结果得出Ae的结论。与Ae相比，白化病的作用相对较小。 DENV传播中的埃及，至少部分是由于宿主偏好的差异和载体能力的降低。但是，最近的树木病毒迅速适应替代蚊媒的例子要求谨慎推断我们的结论。病媒状态是一个动态过程，将来可能以流行病学上重要的方式发生变化。

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