Gender-Associated Genes in Filarial Nematodes Are Important for Reproduction and Potential Intervention Targets

Ben-Wen Li; Amy C. Rush; Dao-Jun Jiang; Makedonka Mitreva; Sahar Abubucker; Gary J. Weil

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Gender-Associated Genes in Filarial Nematodes Are Important for Reproduction and Potential Intervention Targets

机译：丝虫线虫中与性别相关的基因对于生殖和潜在的干预目标很重要

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Background A better understanding of reproductive processes in parasitic nematodes may lead to development of new anthelmintics and control strategies for combating disabling and disfiguring neglected tropical diseases such as lymphatic filariasis and onchocerciasis. Transcriptomatic analysis has provided important new insights into mechanisms of reproduction and development in other invertebrates. We have performed the first genome-wide analysis of gender-associated (GA) gene expression in a filarial nematode to improve understanding of key reproductive processes in these parasites.

机译：背景技术对寄生线虫的生殖过程的更好理解可能会导致开发新的驱虫药和控制策略，以对抗致残和毁容被忽视的热带疾病，如淋巴丝虫病和盘尾丝虫病。笔录分析为其他无脊椎动物的繁殖和发育机制提供了重要的新见解。我们已经对丝虫线虫中的性别相关（GA）基因表达进行了首次全基因组分析，以增进对这些寄生虫关键生殖过程的了解。

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《PLOS Neglected Tropical Diseases》 |2011年第1期|共15页
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Ben-Wen Li; Amy C. Rush; Dao-Jun Jiang; Makedonka Mitreva; Sahar Abubucker; Gary J. Weil;
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1. Wolbachia bacteria of filarial nematodes in the pathogenesis of disease and as a target for control. [J] . Taylor MJ Transactions of the Royal Society of Tropical Medicine and Hygiene . 2000,第6期

机译：丝状线虫的Wolbachia细菌在疾病的发病机理中并作为控制的靶标。
2. Caspase Dependent Programmed Cell Death in Developing Embryos: A Potential Target for Therapeutic Intervention against Pathogenic Nematodes [J] . Alok Das Mohapatra, Sunil Kumar, Ashok Kumar Satapathy, PLOS Neglected Tropical Diseases . 2011,第9期

机译：半胱天冬酶依赖性程序性细胞死亡在发展中国家的胚胎：对病原线虫的治疗干预的潜在目标。
3. PAT-12, a potential anti-nematode target, is a new spectraplakin partner essential for Caenorhabditis elegans hemidesmosome integrity and embryonic morphogenesis. [J] . Hetherington S, Gally C, Fritz JA, Developmental biology . 2011,第2期

机译：PAT-12，一种潜在的抗线虫靶标，是秀丽隐杆线虫半球体完整性和胚胎形态发生必不可少的新的光谱素伴侣。
4. Kinetics of Gender-Regulated Gene Expression in the Filarial Nematode Brugia malayi [C] . B.W. Li, A.C. Rush, G.J. Wei International Congress of Parasitology . 2006

机译：在丝状线虫的性别监管基因表达的动力学在丝状线虫堡垒马来西亚
5. The development and utilization of an in vivo RNA interference protocol to elucidate gene functions and identify potential drug targets in the filarial nematode Brugia malayi. [D] . Song, Chuanzhe. 2011

机译：体内RNA干扰方案的开发和利用，以阐明基因功能并确定丝虫线虫中的潜在药物靶标。
6. Gender-Associated Genes in Filarial Nematodes Are Important for Reproduction and Potential Intervention Targets [O] . Ben-Wen Li, Amy C. Rush, Dao-Jun Jiang, 2011

机译：丝虫线虫中与性别相关的基因对于生殖和潜在的干预目标很重要
7. Gender-associated genes in filarial nematodes are important for reproduction and potential intervention targets [O] . Li Ben-Wen, Rush Amy C, Jiang Dao-Jun, 2011

机译：丝虫线虫中与性别相关的基因对于生殖和潜在的干预目标很重要
8. Crosscutting Interventions and Programs: Potential High Impact Interventions Report. AHRQ Healthcare Horizon Scanning System - Potential High Impact Interventions Report. [R] . 2012

机译：横切干预和计划：潜在的高影响干预报告。 aHRQ医疗保健视野扫描系统 - 潜在的高影响干预报告。

Gender-Associated Genes in Filarial Nematodes Are Important for Reproduction and Potential Intervention Targets

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