• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>PLOS Neglected Tropical Diseases >Venom of the Brazilian Spider Sicarius ornatus (Araneae, Sicariidae) Contains Active Sphingomyelinase D: Potential for Toxicity after Envenomation
【24h】

Venom of the Brazilian Spider Sicarius ornatus (Araneae, Sicariidae) Contains Active Sphingomyelinase D: Potential for Toxicity after Envenomation

机译：巴西蜘蛛Sicarius ornatus（Araneae，Sicariidae）的毒液含有活性鞘磷脂酶D：毒化后有潜在的毒性

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background The spider family Sicariidae includes two genera, Sicarius and Loxosceles. Bites by Sicarius are uncommon in humans and, in Brazil, a single report is known of a 17-year old man bitten by a Sicarius species that developed a necrotic lesion similar to that caused by Loxosceles. Envenomation by Loxosceles spiders can result in dermonecrosis and severe ulceration. Sicarius and Loxosceles spider venoms share a common characteristic, i.e., the presence of Sphingomyelinases D (SMase D). We have previously shown that Loxosceles SMase D is the enzyme responsible for the main pathological effects of the venom. Recently, it was demonstrated that Sicarius species from Africa, like Loxosceles spiders from the Americas, present high venom SMase D activity. However, despite the presence of SMase D like proteins in venoms of several New World Sicarius species, they had reduced or no detectable SMase D activity. In order to contribute to a better understanding about the toxicity of New World Sicarius venoms, the aim of this study was to characterize the toxic properties of male and female venoms from the Brazilian Sicarius ornatus spider and compare these with venoms from Loxosceles species of medical importance in Brazil.
机译：背景技术蜘蛛科（Sicariidae）包括两个属，西卡里乌斯（Sicarius）和狐猴（Loxosceles）。西卡里乌斯的叮咬在人类中并不常见，在巴西，据报道，有一个17岁的老人被西卡里乌斯（Sicarius）物种咬伤，其坏死性病变类似于由腰虱引起的坏死。龙虾蜘蛛的毒化可能导致皮肤坏死和严重溃疡。西卡里乌斯（Sicarius）和狐猴（Loxosceles）蜘蛛毒液具有一个共同的特征，即鞘磷脂酶D（SMase D）的存在。先前我们已经表明，腰突SMase D是负责毒液主要病理作用的酶。最近，事实证明，来自非洲的西卡里乌斯物种，例如来自美洲的狐尾蜘蛛，具有很高的毒液SMase D活性。然而，尽管在一些新世界西卡里乌斯物种的毒液中存在SMase D样蛋白，但它们的SMase D活性降低或没有可检测到。为了有助于更好地了解新世界西卡里乌斯毒液的毒性，本研究的目的是鉴定巴西西卡里乌斯蜘蛛的男性和女性毒液的毒性，并将其与具有医学重要性的蛇蝎物种的毒液进行比较。在巴西。

著录项

相似文献

  • 外文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号