Antigenicity and Diagnostic Potential of Vaccine Candidates in Human Chagas Disease

Shivali Gupta; Xianxiu Wan; Maria P. Zago; Valena C. Martinez Sellers; Trevor S. Silva; Dadjah Assiah; Monisha Dhiman; Sonia Nu?ez; John R. Petersen; Juan C. Vázquez-Chagoyán; Jose G. Estrada-Franco; Nisha Jain Garg

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Antigenicity and Diagnostic Potential of Vaccine Candidates in Human Chagas Disease

机译：人类恰加斯病疫苗候选者的抗原性和诊断潜力

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Background Chagas disease, caused by Trypanosoma cruzi, is endemic in Latin America and an emerging infectious disease in the US and Europe. We have shown TcG1, TcG2, and TcG4 antigens elicit protective immunity to T. cruzi in mice and dogs. Herein, we investigated antigenicity of the recombinant proteins in humans to determine their potential utility for the development of next generation diagnostics for screening of T. cruzi infection and Chagas disease.

机译：背景由锥虫锥虫引起的南美锥虫病在拉丁美洲很流行，在美国和欧洲正在成为一种新兴的传染病。我们已经显示，TcG1，TcG2和TcG4抗原在小鼠和狗中引起对克氏锥虫的保护性免疫。在这里，我们调查了人类中重组蛋白的抗原性，以确定其潜在潜力，可用于开发用于筛查克氏锥虫感染和南美锥虫病的下一代诊断方法。

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《PLOS Neglected Tropical Diseases》 |2013年第1期|共10页
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Shivali Gupta; Xianxiu Wan; Maria P. Zago; Valena C. Martinez Sellers; Trevor S. Silva; Dadjah Assiah; Monisha Dhiman; Sonia Nu?ez; John R. Petersen; Juan C. Vázquez-Chagoyán; Jose G. Estrada-Franco; Nisha Jain Garg;
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1. Cysteine mutagenesis improves the production without abrogating antigenicity of a recombinant protein vaccine candidate for human chagas disease [J] . Seid Christopher A., Jones Kathryn M., Pollet Jeroen, Human vaccines & immunotherapeutics. . 2017,第3期

机译：半胱氨酸诱变改善了生产而不消除重组蛋白质疫苗候选人的抗原性的人噬菌体疾病
2. Cloning, expression, and characterization of TonB2 from Actinobacillus pleuropneumoniae and potential use as an antigenic vaccine candidate and diagnostic marker [J] . Liu Jinlin, Chen Yan, Yuan Fangyan, Canadian Journal of Veterinary Research . 2011,第3期

机译：胸膜肺炎放线杆菌TonB2的克隆，表达和鉴定及其作为抗原疫苗候选物和诊断标记的潜在用途
3. Cloning, expression, and characterization of TonB2 from Actinobacillus pleuropneumoniae and potential use as an antigenic vaccine candidate and diagnostic marker [J] . Jinlin Liu, Yan Chen, Fangyan Yuan, Canadian Journal of Veterinary Research . 2011,第3期

机译：胸膜肺炎放线杆菌的TonB2的克隆，表达和鉴定及其作为抗原疫苗候选物和诊断标记的潜在用途
4. Synthesis and refolding of G20,a potential antigen for human Respiratory Syncytial Virus (hRSV) vaccine [C] . Christine Klinguer-Hamour, Marie-Claire Bussat, Helene Plotnicky-Gilquin, European Peptide Symposium . 2002

机译：G20的合成和重折叠，人类呼吸合胞病毒（HRSV）疫苗的潜在抗原
5. Studies of human rotavirus candidate non-replicating vaccines and innate immunity in a gnotobiotic pig model of human rotavirus disease . [D] . Gonzalez, Ana Maria. 2007

机译：人轮状病毒候选非复制疫苗和人免疫原性免疫的研究
6. Antigenicity and Diagnostic Potential of Vaccine Candidates in Human Chagas Disease [O] . Shivali Gupta, Xianxiu Wan, Maria P. Zago, 2013

机译：人类恰加斯病疫苗候选者的抗原性和诊断潜力
7. Antigenicity and diagnostic potential of vaccine candidates in human Chagas disease [O] . Gupta, Shivali, Wan, Xianxu, Zago, María Paola, 2016

机译：候选疫苗在人类恰加斯病中的抗原性和诊断潜力
8. Basic Research Effort Toward Development of a Vaccine Against Human Brucellosis;Identification of Protective Brucella Antigens and Their Expression in Vaccinia Virus to Prevent Disease in Animals and Humans [R] . Schurig, G. G. 1997

机译：针对人类布鲁氏菌病疫苗开发的基础研究工作;保护布鲁氏菌抗原的鉴定及其在痘苗病毒中的表达，以预防动物和人类疾病

Antigenicity and Diagnostic Potential of Vaccine Candidates in Human Chagas Disease

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