EmTIP, a T-Cell Immunomodulatory Protein Secreted by the Tapeworm Echinococcus multilocularis Is Important for Early Metacestode Development

Justin Komguep Nono; Manfred B. Lutz; Klaus Brehm

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EmTIP, a T-Cell Immunomodulatory Protein Secreted by the Tapeworm Echinococcus multilocularis Is Important for Early Metacestode Development

机译：EmTIP，一种由worm虫棘球Secret虫分泌的T细胞免疫调节蛋白，对于早期的蜕皮动物发展很重要。

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Background Alveolar echinococcosis (AE), caused by the metacestode of the tapeworm Echinococcus multilocularis, is a lethal zoonosis associated with host immunomodulation. T helper cells are instrumental to control the disease in the host. Whereas Th1 cells can restrict parasite proliferation, Th2 immune responses are associated with parasite proliferation. Although the early phase of host colonization by E. multilocularis is dominated by a potentially parasitocidal Th1 immune response, the molecular basis of this response is unknown.

机译：背景技术由the虫棘球E虫的前肠c引起的肺泡棘球co病（AE）是与宿主免疫调节相关的致死性人畜共患病。 T辅助细胞有助于控制宿主中的疾病。 Th1细胞可以限制寄生虫的增殖，而Th2免疫反应与寄生虫的增殖有关。尽管多叶大肠杆菌的宿主定殖的早期阶段主要由潜在的杀寄生虫Th1免疫应答决定，但这种应答的分子基础尚不清楚。

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《PLOS Neglected Tropical Diseases》 |2014年第1期|共12页
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Justin Komguep Nono; Manfred B. Lutz; Klaus Brehm;
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1. Molecular Characterization of EmABP, an Apolipoprotein A-I Binding Protein Secreted by the Echinococcus multilocularis Metacestode [J] . Peter Bernthaler, Kerstin Epping, Gerd Schmitz, Infection and immunity . 2009,第12期

机译：EmABP的分子表征，一种载脂蛋白A-I结合蛋白，由多棘球chin球的Metacestode分泌。
2. Components of the mitogen-activated protein kinase cascade are activated in hepatic cells by Echinococcus multilocularis metacestode. [J] . Lin RY, Wang JH, Lu XM, World journal of gastroenterology : . 2009,第17期

机译：有丝分裂原激活的蛋白激酶级联反应的成分在肝细胞中被多叶棘球meta球（Echinococcus multilocularis metacestode）激活。
3. Establishment and development of Echinococcus multilocularis metacestodes in the common vole (Microtus arvalis) after oral inoculation with parasite eggs [J] . Woolsey Ian David, Jensen Per Moestrup, Deplazes Peter, Parasitology International . 2015,第6期

机译：寄生虫卵经口接种后普通田鼠（田鼠）多棘棘球chin虫的代谢产物的建立和发育
4. Actinodaphnine and Rutacridone as New T-Cell Protein Tyrosine Phosphatase Inhibitors for Drug Development of Obesity [C] . Y Fitrianingrum, D Indarto, R Kusumawati Annual Basic Science International Conference . 2019

机译：Actinodaphnine和Rutacridone作为新的T细胞蛋白酪氨酸磷酸酶抑制剂，用于肥胖的药物发育
5. STUDIES ON THE IMMUNOBIOLOGY OF INFECTIONS WITH THE METACESTODES OF ECHINOCOCCUS MULTILOCULARIS IN RODENTS. [D] . KROEZE, WESLEY KARS. 1987

机译：啮齿类动物多棘壳棘球TA虫感染的免疫学研究。
6. EmTIP a T-Cell Immunomodulatory Protein Secreted by the Tapeworm Echinococcus multilocularis Is Important for Early Metacestode Development [O] . Justin Komguep Nono, Manfred B. Lutz, Klaus Brehm 2014

机译：EmTIP一种由worm虫棘球Secret虫分泌的T细胞免疫调节蛋白对于早期的蜕皮动物发展很重要。
7. EmTIP, a T-Cell immunomodulatory protein secreted by the tapeworm Echinococcus multilocularis is important for early metacestode development. [O] . Justin Komguep Nono, Manfred B Lutz, Klaus Brehm 2014

机译：由绦虫多房棘球绦虫（Echinococcus multilocularis）分泌的T细胞免疫调节蛋白EmTIp对早期的metacestode发育很重要。

EmTIP, a T-Cell Immunomodulatory Protein Secreted by the Tapeworm Echinococcus multilocularis Is Important for Early Metacestode Development

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