Therapeutic Administration of Recombinant Paracoccin Confers Protection against Paracoccidioides brasiliensis Infection: Involvement of TLRs

Ana Claudia Paiva Alegre-Maller; Flávia Costa Mendon?a; Thiago Aparecido da Silva; Aline Ferreira Oliveira; Mateus Silveira Freitas; Ebert Seixas Hanna; Igor C. Almeida; Nicholas J. Gay; Maria Cristina Roque-Barreira

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Therapeutic Administration of Recombinant Paracoccin Confers Protection against Paracoccidioides brasiliensis Infection: Involvement of TLRs

机译：重组副球菌的治疗性给药可预防巴西副球菌感染：TLR的参与

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Background Paracoccin (PCN) is an N-acetylglucosamine-binding lectin from the human pathogenic fungus Paracoccidioides brasiliensis. Recombinant PCN (rPCN) induces a T helper (Th) 1 immune response when prophylactically administered to BALB/c mice, protecting them against subsequent challenge with P. brasiliensis. In this study, we investigated the therapeutic effect of rPCN in experimental paracoccidioidomycosis (PCM) and the mechanism accounting for its beneficial action.

机译：背景副球菌（PCN）是一种N-乙酰氨基葡糖结合凝集素，来自人类病原性真菌巴西副球菌（Paracoccidioides brasiliensis）。重组PCN（rPCN）预防性施用于BALB / c小鼠后，会诱导T辅助（Th）1免疫应答，从而保护它们免于随后受到巴西假单胞菌的攻击。在这项研究中，我们调查了rPCN在实验性球虫副菌病（PCM）中的治疗作用及其作用机理。

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《PLOS Neglected Tropical Diseases》 |2014年第12期|共11页
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Ana Claudia Paiva Alegre-Maller; Flávia Costa Mendon?a; Thiago Aparecido da Silva; Aline Ferreira Oliveira; Mateus Silveira Freitas; Ebert Seixas Hanna; Igor C. Almeida; Nicholas J. Gay; Maria Cristina Roque-Barreira;
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1. Protection against Paracoccidioides brasiliensis infection conferred by the prophylactic administration of native and recombinant ArtinM. [J] . Coltri KC, Oliveira LL, Ruas LP, Medical mycology: official publication of the International Society for Human and Animal Mycology . 2010,第6期

机译：预防性施用天然和重组ArtinM可以预防巴西副球菌感染。
2. Recombinant Paracoccin Reproduces the Biological Properties of the Native Protein and Induces Protective Th1 Immunity against Paracoccidioides brasiliensis Infection [J] . Ana Claudia Paiva Alegre, Aline Ferreira Oliveira, Fausto Bruno Dos Reis Almeida, PLOS Neglected Tropical Diseases . 2014,第4期

机译：重组副球菌可复制天然蛋白的生物学特性，并诱导针对巴西副球菌感染的保护性Th1免疫
3. Therapeutic administration of KM+ lectin protects mice against Paracoccidioides brasiliensis infection via interleukin-12 production in a toll-like receptor 2-dependent mechanism. [J] . Coltri KC, Oliveira LL, Pinzan CF, American Journal of Pathology: Official Publication of the American Association of Pathologists . 2008,第2期

机译：KM +凝集素的治疗性给药可通过白细胞介素12产生的Toll样受体2依赖性机制，保护小鼠免受巴西副球菌感染。
4. Two intra-nasal administrations of plla co-encapsulated y. pestis sub-units confers protection from plague [C] . H. O. Alpar, J.E. Eyles, I.D. Spiers, International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 1998

机译：两次鼻内给药的Pla共包封y。瘟疫亚单位可预防鼠疫
5. Characterizing accidents, exposures, and laboratory-acquired infections reported to the national institutes of health's office of biotechnology activities (NIH/OBA) involving recombinant DNA biological agents. [D] . Campbell, Mark J. 2014

机译：向国家卫生研究院生物技术活动办公室（NIH / OBA）报告涉及重组DNA生物制剂的事故，暴露和实验室获得的感染的特征。
6. Therapeutic Administration of Recombinant Paracoccin Confers Protection against Paracoccidioides brasiliensis Infection: Involvement of TLRs [O] . Ana Claudia Paiva Alegre-Maller, Flávia Costa Mendonça, Thiago Aparecido da Silva, 2014

机译：重组副球菌的治疗性给药可预防巴西副球菌感染：TLR的参与
7. Therapeutic administration of recombinant Paracoccin confers protection against paracoccidioides brasiliensis infection: involvement of TLRs. [O] . Ana Claudia Paiva Alegre-Maller, Flávia Costa Mendonça, Thiago Aparecido da Silva, 2014

机译：重组paracoccin的治疗性施用赋予针对巴西球菌感染的保护：TLR的参与。

Therapeutic Administration of Recombinant Paracoccin Confers Protection against Paracoccidioides brasiliensis Infection: Involvement of TLRs

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