Effect of Non-tuberculous Mycobacteria on Host Biomarkers Potentially Relevant for Tuberculosis Management

S. Dhanasekaran; Synne Jenum; Ruth Stavrum; Harald G. Wiker; John Kenneth; Mario Vaz; T. Mark Doherty; Harleen M. S. Grewal; TB Trials Study Group

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Effect of Non-tuberculous Mycobacteria on Host Biomarkers Potentially Relevant for Tuberculosis Management

机译：非结核分枝杆菌对可能与结核病管理有关的宿主生物标志物的影响

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Background Non-tuberculous mycobacteria (NTM) are different from Mycobacterium tuberculosis (MTB) both in their ubiquitous environmental distribution and in their reduced capacity to cause disease. While often neglected in favour of other infectious diseases, NTM may interfere with important aspects of TB control and management, namely the efficacy of new anti-tuberculosis (TB) vaccines; the immuno-diagnostic Tuberculin skin test (TST) and QuantiFERON TB Gold In Tube assay (QFTGIT); and immune biomarkers explored for their diagnostic and/or predictive potential. Our objective was therefore to explore host immune biomarkers in children who had NTM isolated from respiratory and/or gastric specimens.

机译：背景技术非结核分枝杆菌（NTM）与结核分枝杆菌（MTB）在普遍存在的环境分布和降低的致病能力上都不同。尽管NTM常常被忽视而倾向于其他传染病，但它可能会干扰结核病控制和管理的重要方面，即新型抗结核疫苗的功效;免疫诊断结核菌素皮肤试验（TST）和QuantiFERON TB黄金管试验（QFTGIT）;探索了免疫生物标记物的诊断和/或预测潜力。因此，我们的目标是探索从呼吸道和/或胃部标本中分离出NTM的儿童的宿主免疫生物标志物。

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《PLOS Neglected Tropical Diseases》 |2014年第10期|共9页
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S. Dhanasekaran; Synne Jenum; Ruth Stavrum; Harald G. Wiker; John Kenneth; Mario Vaz; T. Mark Doherty; Harleen M. S. Grewal; TB Trials Study Group;
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2. Role of GenoType? Mycobacterium Common Mycobacteria/Additional Species Assay for Rapid Differentiation Between Mycobacterium tuberculosis Complex and Different Species of Non-Tuberculous Mycobacteria [J] . Amresh Kumar Singh, * Anand Kumar Maurya, * Jyoti Umrao, Journal of Laboratory Physicians . 2013,第2期

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3. Mixed infections of Corynebacterium pseudotuberculosis and non-tuberculous mycobacteria in South African antelopes presenting with tuberculosis-like lesions. [J] . Muller B, Klerk-Lorist L. M. de Henton M. M, Lane E, Veterinary Microbiology . 2011,第3a4期

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4. The Role of Non-Tuberculous Mycobacteria in Peritoneal Dialysis-Related Infections: A Literature Review [C] . Naoki Washida, Hiroshi ltoh Nihon To?seki Igakkai., Gakujutsu Shu?kai So?kai . 2018

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5. Residential Exposure to Non-Tuberculous Mycobacteria: Sources and Associations with Pulmonary Disease [D] . Tzou, Connie L. 2018

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6. Effect of Non-tuberculous Mycobacteria on Host Biomarkers Potentially Relevant for Tuberculosis Management [O] . S. Dhanasekaran, Synne Jenum, Ruth Stavrum, 2014

机译：非结核分枝杆菌对可能与结核病管理有关的宿主生物标志物的影响
7. Effect of non-tuberculous Mycobacteria on host biomarkers potentially relevant for tuberculosis management. [O] . S Dhanasekaran, Synne Jenum, Ruth Stavrum, 2014

机译：非结核分枝杆菌对可能与结核病管理相关的宿主生物标志物的影响。

Effect of Non-tuberculous Mycobacteria on Host Biomarkers Potentially Relevant for Tuberculosis Management

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