T cell receptor repertoire among women who cleared and failed to clear cervical human papillomavirus infection: An exploratory proof-of-principle study

Krystle A. Lang Kuhs; Shih-Wen Lin; Xing Hua; Mark Schiffman; Robert D. Burk; Ana Cecilia Rodriguez; Rolando Herrero; Christian C. Abnet; Neal D. Freedman; Ligia A. Pinto; David Hamm; Harlan Robins; Allan Hildesheim; Jianxin Shi; Mahboobeh Safaeian

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T cell receptor repertoire among women who cleared and failed to clear cervical human papillomavirus infection: An exploratory proof-of-principle study

机译：清除和未能清除宫颈人乳头瘤病毒感染的女性中的T细胞受体库：一项探索性原理验证研究

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BackgroundIt is unknown why a minority of women fail to clear human papillomavirus (HPV) and develop precancer/cancer. Differences in T-cell receptor (TCR) repertoires may identify HPV16-infected women at highest-risk for progression to cancer. We conducted a proof-of-principle study nested within the Guanacaste HPV Natural History Study to evaluate the utility of next-generation sequencing for interrogating the TCR repertoires among women who cleared and failed to clear cervical HPV16.

机译：背景未知为什么少数女性无法清除人乳头瘤病毒（HPV）并发展为癌前期/癌症。 T细胞受体（TCR）谱表的差异可能会确定感染HPV16的女性罹患癌症的风险最高。我们在瓜纳卡斯特（Guanacaste）HPV自然史研究中进行了一项原理验证研究，以评估下一代测序在询问已清除和未清除宫颈HPV16的女性中询问TCR记忆库的效用。

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《PLoS One》 |2018年第1期|共页
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Krystle A. Lang Kuhs; Shih-Wen Lin; Xing Hua; Mark Schiffman; Robert D. Burk; Ana Cecilia Rodriguez; Rolando Herrero; Christian C. Abnet; Neal D. Freedman; Ligia A. Pinto; David Hamm; Harlan Robins; Allan Hildesheim; Jianxin Shi; Mahboobeh Safaeian;
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1. T-Cell Response to Human Papillomavirus Type 58 L1, E6, and E7 Peptides in Women with Cleared Infection, Cervical Intraepithelial Neoplasia, or Invasive Cancer [J] . Paul K. S. Chan, Shih-Jen Liu, T. H. Cheung, Clinical and vaccine immunology: CVI . 2010,第9期

机译：明确感染，宫颈上皮内瘤变或浸润性癌妇女对人乳头瘤病毒58型L1，E6和E7肽的T细胞反应
2. T-Cell Response to Human Papillomavirus Type 58 L1, E6, and E7 Peptides in Women with Cleared Infection, Cervical Intraepithelial Neoplasia, or Invasive Cancer [J] . Paul K. S. Chan, Shih-Jen Liu, T. H. Cheung, Clinical and vaccine immunology: CVI . 2010,第9期

机译：明确感染，宫颈上皮内瘤变或浸润性癌妇女对人乳头瘤病毒58型L1，E6和E7肽的T细胞反应
3. Cell-mediated immune responses to human papillomavirus 16 E6 and E7 antigens as measured by interferon gamma enzyme-linked immunospot in women with cleared or persistent human papillomavirus infection. [J] . Farhat S, Nakagawa M, Moscicki AB International journal of gynecological cancer: official journal of the International Gynecological Cancer Society . 2009,第4期

机译：干扰素γ酶联免疫斑点法在患有明确或持续性人乳头瘤病毒感染的妇女中测定了对人乳头瘤病毒16 E6和E7抗原的细胞介导的免疫反应。
4. Human Papillomavirus Testing in Primary Screening of High-Grade Cervical Lesions: A Study of 12538 Women [C] . C. Clavel, J. Cucherousset, J.P. Bory, International Multidisciplinary Congress . 2003

机译：高档宫颈病变初级筛查人乳头瘤病毒检测：12538名女性的研究
5. Prevention of human papillomavirus (HPV) infection and HPV-related diseases: Barriers to HPV vaccine coverage among university women in the U.S., and Initial steps in integrating cervical cytology testing into primary care in the Republic of Georgia. [D] . Bednarczyk, Robert A. 2010

机译：预防人乳头瘤病毒（HPV）感染和与HPV相关的疾病：美国大学女性中HPV疫苗覆盖率的障碍，以及在佐治亚州将宫颈细胞学检测纳入初级保健的初始步骤。
6. T cell receptor repertoire among women who cleared and failed to clear cervical human papillomavirus infection: An exploratory proof-of-principle study [O] . Krystle A. Lang Kuhs, Shih-Wen Lin, Xing Hua, 2012

机译：清除和未能清除宫颈人乳头瘤病毒感染的女性中的T细胞受体库：一项探索性原理验证研究
7. T cell receptor repertoire among women who cleared and failed to clear cervical human papillomavirus infection: An exploratory proof-of-principle study [O] . Krystle A. Lang Kuhs, Shih-Wen Lin, Xing Hua, 2018

机译：清除和未能清除宫颈人乳头瘤病毒感染的妇女中的T细胞受体曲目：探索性原则上的探索性研究

T cell receptor repertoire among women who cleared and failed to clear cervical human papillomavirus infection: An exploratory proof-of-principle study

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