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首页> 外文期刊>PLOS Neglected Tropical Diseases >Concerns for efficacy of a 30-valent M-protein-based Streptococcus pyogenes vaccine in regions with high rates of rheumatic heart disease
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Concerns for efficacy of a 30-valent M-protein-based Streptococcus pyogenes vaccine in regions with high rates of rheumatic heart disease

机译：对30价基于M蛋白的化脓性链球菌疫苗在风湿性心脏病高发地区的疗效表示担忧

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Author summary The bacterium Streptococcus pyogenes causes throat and skin infections. A danger from such infections is an immune response that attacks human heart tissue, leading to rheumatic heart disease, which is difficult to treat and potentially deadly. Disadvantaged populations such as the Indigenous people in remote tropical northern Australia have high burdens of S. pyogenes skin infection, and rheumatic heart disease. An effective vaccine would be a benefit, but none is approved for clinical use. We analysed data from 1810 S. pyogenes isolates from north Australia obtained over 28 years, to determine the potential of a previously described S. pyogenes vaccine candidate to be effective in this region. Only one quarter of the isolates from skin infections had a surface antigen corresponding to any one of the 30 antigen variants in the candidate vaccine. Previous work in animals indicates potential cross-protection from the vaccine against strains with mismatched antigens. However, even if this occurs in humans, protection against skin infection strains would likely remain compromised, unless there were additional components in the vaccine. Further studies on cross-protection are critical to defining the potential of this type of vaccine in populations burdened with S. pyogenes skin infections and rheumatic heart disease.
机译：作者摘要化脓性链球菌细菌会引起咽喉和皮肤感染。这种感染的危险是攻击人体心脏组织的免疫反应，导致风湿性心脏病，这种疾病很难治疗，甚至可能致命。诸如澳大利亚北部偏远热带地区的土著人等处境不利的人群承受着化脓性链球菌皮肤感染和风湿性心脏病的高负担。有效的疫苗将是有益的，但没有一种疫苗被批准用于临床。我们分析了从28年来获得的来自北澳大利亚的1810个化脓性链球菌的数据，以确定先前描述的化脓性链球菌疫苗候选物在该地区有效的潜力。来自皮肤感染的分离株中只有四分之一的表面抗原对应于候选疫苗中的30种抗原变体中的任何一种。先前在动物中的研究表明，疫苗针对抗原错配的菌株可能具有交叉保护作用。但是，即使这种情况在人类中发生，除非疫苗中没有其他成分，否则针对皮肤感染株的保护可能仍会受到损害。交叉保护的进一步研究对于确定这种类型的疫苗在化脓性链球菌皮肤感染和风湿性心脏病负担人群中的潜力至关重要。

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