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首页> 外文期刊>PLoS One >Methicillin Resistant Staphylococcus aureus ST398 in Veal Calf Farming: Human MRSA Carriage Related with Animal Antimicrobial Usage and Farm Hygiene
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Methicillin Resistant Staphylococcus aureus ST398 in Veal Calf Farming: Human MRSA Carriage Related with Animal Antimicrobial Usage and Farm Hygiene

机译：小牛饲养中耐甲氧西林的金黄色葡萄球菌ST398：与动物抗菌素使用和农场卫生有关的人类MRSA携带

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Introduction Recently a specific MRSA sequence type, ST398, emerged in food production animals and farmers. Risk factors for carrying MRSA ST398 in both animals and humans have not been fully evaluated. In this cross-sectional study, we investigated factors associated with MRSA colonization in veal calves and humans working and living on these farms. Methods A sample of 102 veal calf farms were randomly selected and visited from March 2007–February 2008. Participating farmers were asked to fill in a questionnaire (n = 390) to identify potential risk factors. A nasal swab was taken from each participant. Furthermore, nasal swabs were taken from calves (n = 2151). Swabs were analysed for MRSA by selective enrichment and suspected colonies were confirmed as MRSA by using slide coagulase test and PCR for presence of the mecA-gene. Spa types were identified and a random selection of each spa type was tested with ST398 specific PCR. The Sequence Type of non ST398 strains was determined. Data were analyzed using logistic regression analysis. Results Human MRSA carriage was strongly associated with intensity of animal contact and with the number of MRSA positive animals on the farm. Calves were more often carrier when treated with antibiotics, while farm hygiene was associated with a lower prevalence of MRSA. Conclusion This is the first study showing direct associations between animal and human carriage of ST398. The direct associations between animal and human MRSA carriage and the association between MRSA and antimicrobial use in calves implicate prudent use of antibiotics in farm animals.
机译：简介最近，在食品生产动物和农民中出现了一种特定的MRSA序列类型ST398。在动物和人类中携带MRSA ST398的危险因素尚未得到充分评估。在这项横断面研究中，我们调查了与小牛和在这些农场工作和生活的人类中MRSA定殖相关的因素。方法从2007年3月至2008年2月，随机抽取102个小牛养殖场的样本进行访问。对参与调查的农户进行问卷调查（n = 390）以识别潜在的危险因素。从每个参与者中取出鼻拭子。此外，还从小牛处采集了鼻拭子（n = 2151）。通过选择性富集分析拭子的MRSA，并通过玻片凝固酶试验和PCR检测mecA基因的存在，将可疑菌落确认为MRSA。确定温泉类型，并使用ST398特异性PCR测试每种温泉类型的随机选择。确定非ST398菌株的序列类型。使用逻辑回归分析分析数据。结果人类MRSA携带与动物接触的强度以及农场中MRSA阳性动物的数量密切相关。当使用抗生素治疗时，犊牛更经常成为携带者，而农场卫生与MRSA的患病率较低相关。结论这是第一个显示动物和人类携带ST398直接相关的研究。动物和人类MRSA携带之间的直接关联以及牛犊中MRSA和抗菌素使用之间的关联暗示着谨慎地在农场动物中使用抗生素。

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